The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

In this thirteenth book of scilogs – one may find topics on Neutrosophy, Plithogeny, Physics, Mathematics, Philosophy – email messages to research colleagues, or replies, notes, comments, remarks about authors, articles, or books, spontaneous ideas, and so on. It presents new types of soft sets and new types of topologies. -/- Exchanging ideas with Mohammad Abobala, Ishfaq Ahmad, Ibrahim M. Almanjahie, Fatimah Alshahrani, Nizar Altounji, Muhammad Aslam, Said Broumi, Victor Christianto, R. Diksh, Feng Liu, Frank Julian Gelli, Erick Gonzalez Caballero, (...) Riad Hamido, Yaser Al-Hasan, Ahmed Hatip, Yasin Karmouta, Nivetha Martin, Preda Mihăilescu, V. Lakshmana Gomathi Nayagam, Ze Carlos Tiago de Oliveira, Alexey Platonov, Andrei Pogany, Shakti Prasad, Ranulfo Paiva Barbosa (Sobrinho), Dmitri Rabounski, Ackbar Rezaei, Constantin Sandu, A. Saraswathi, Usman Shahzad, Gocho V. Sharlanov, Stefan Spaarmann, Michael Voskoglou, Vinay Kumar Yadav, Tomasz Witczak, William H. Woodall, Mircea Zărnescu, Mohamed Bisher Zeina (in order of reference in the book). (shrink)

Guru Nanak was not content to remain a mystic. He undertook [9-11] four long travels, called udasis, to spread his message far and wide and to share his spiritual experiences with others. Bhai Mardana always accompanied the Guru during missionary tours. During the four travels, Guru Nanak visited different religious places. He went to Kurukshetra, Haridwar, Joshi Math, Ratha Sahib, Gorakh Matta (Nanak Matta), Audhya, Prayag, Varanasi, Gaya, Patna, Dhubri and Gauhati in Assam, Dacca, Puri, Cuttock, Rameshwaram, Ceylon, Bidar, Baroach, (...) Somnath, Dwarka, Janagarh, Ujjain, Ajmer, Mathura, Pakpattan, Talwandi, Lahore, Sultanpur, Bilaspur, Rawalsar, Jawalaji, Spiti Vally, Tibet, Ladakh, Kargil, Amarnath, Srinagar and Baramula. Guru Nanak also paid visits to Muslim holy places. He went to Mecca, Medina, Beghdad via Multan, Peshawar Sakhar, Son Miani, Hinglaj etc. Some accounts say that Guru Sahib reached Mecca by sea route. He also visited Syria, Turkey and Tehran (Iran). From Tehran he set out on the caravan route and covered Kabul, Kandhar and Jalalabad. The aim of his tours was to awaken the people, and to realize the truth about God and his creation. He established a network of preaching centres of his philosophy called “Manjis”. He appointed able and committed followers as their in-charges. The basic tenets of Guru Nanak's philosophy were wilfully conceived by people from all walks of life. Thus the seeds of Sikhism were sown all over India and abroad in a well-planned manner. In 1516, Guru Nanak laid the foundation of a city, In the central Punjab, near Pakhoke Randhawa, for wider dissemination of his message. He built a Dharamsala (a place for the religious congregation), established the Holy Fellowship of the people there, and named the city the Abode of the Creator — 'Kartarpur'. But he and Bhai Mardana soon left it for his travel to Mecca in autumn of 1518 A.D. In the year 1520, Babar attacked India. His troops slaughtered thousands of innocent civilians. Women and children were made captives, and all their property was plundered at Eminabad (now in Pakistan). Guru Nanak, who was at Eminabad at that time, challenged this act of barbarity by Babar in strong words. He was arrested and released shortly after, making Babar realize his blunder. All the prisoners were also released. Guru Nanak came back to Kartarpur in 1521 A.D. (shrink)