Alan Hodgkin and Andrew Huxley used abductive reasoning to draw conclusions about the ionic basis of the action potential. Here we build on that initial proposal. First, we propose that Hodgkin and Huxley’s constitutive abductive reasoning has four features. Second, we argue that Hodgkin and Huxley are not alone in giving such arguments. Tolman, 1948, and Baumgartner, 1960, also gave such arguments. The implication is that such arguments are common enough in science that philosophers of science should pay more attention (...) to them. Third, we propose that constitutive abduction describes a method that scientists use to confirm constitutive hypotheses that is an alternative to the mutual manipulability approach that is familiar in the New Mechanist literature. (shrink)

Some New Mechanists have proposed that claims of compositional relations are justified by combining the results of top-down and bottom-up interlevel interventions. But what do scientists do when they can perform, say, a cellular intervention, but not a subcellular detection? In such cases, paired interlevel interventions are unavailable. We propose that scientists use abduction and we illustrate its use through a case study of the ionic theory of resting and action potentials.

The perhaps most challenging problem for a panentheistic paradigm in Christian god-talk consists in integrating the trait of personhood in the monistic horizon of this approach. A very helpful way to this goal seems to be the concept of imagination. Its logic of an “as if” represents a modified variation of Kant`s idea of the postulates of reason. Reflections of Jürgen Werbick, Douglas Headley, and Volker Gerhardt substantiate the philosophical and theological capabilities of this solution which also include a (...) sensibility for the ontological commitments included in the panentheistic approach. (shrink)