Health and disease are prime focus in the field of Indian medicine and exploration of cause as primary thirst in human being. Cause and effect in Ayurveda is discussed throughout Ayurvedic texts. A critical appraisal of karana(cause) from different point of view was done and it has been concluded that effect conceived in form of sign/symptoms in healthy or diseased must have certain cause. No individual cause can bring an effect until there is an interrelationship, inter-contact and interaction among causes. (...) Causes in Ayurveda has been explored in different contexts in form of causative factors for disease, dhatusamyata (health), cause for origin of shrishti (universe), purusha (human), garbha(foetus), karyadravya(existing matter), one cause for many effect, use of different synonyms like hetu, nidana, ayatana, nimitta, role of cause in therapeutics, cause as one important examination tool of dasha parikshya vishaya, cause as primary focus for research etc. were intervened. What is this cause? In which form has cause been described in Ayurveda? What are different names for these causes in Ayurveda? What are the different effects produced by causes? Analysis of karana from different point of view has been objective of this paper.. (shrink)