Objective: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. Summary of key data: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in healthcare systems –has been ignorant of scarcity and dose optimisation's ability to help address it. Conclusions: Future pandemic clinical trials systems should obtain dose optimisation data, as these (...) appear necessary to enable appropriate scarce resource allocation according to societal values. (shrink)

Né dans le sillage d’un « significant renewal of interest in Bergsonism and a greater recognition of his influence on twentieth-century philosophy » (p. 1), ce livre ne pouvait que poser des questions sur le temps, ramenant également à la philosophie de Heidegger, à qui l’on doit l’une des pensées les plus originales à ce sujet. Aussi Heath Massey s’emploie-t-il lire les textes de Bergson qui tentent de repenser la notion traditionnelle de temps à côté de ceux de Heidegger, (...) mettant plus particulièrement en lumière l’influence de celui-là sur celui-ci, une influence largement passée inaperçue. L’importance de cette œuvre tient dans la façon dont l’A. conteste la philosophie du temps que Heidegger attribue à Bergson. Notre guide considère la lecture bergsonienne de Heidegger comme une « oversimplication » (p. 84) et vise à éclaircir comment, malgré les propos du penseur allemand, le philosophe français a été capable de radicalement repenser le temps d’un point de vue ontologique. Dès lors, l’ouvrage s’achève sur un goût de soupçon, celui-ci faisant dire que Heidegger a essayé de se distinguer de Bergson pour ne pas admettre ce dont il lui est redevable. (shrink)

More than thirty-five years after its first release in 1971, Don McLean’s “American Pie” still resonates deeply with music listeners and consumers of popular culture. In a 2001 public poll sponsored by the National Endowment for the Arts and the Recording Industry Association of America, McLean’s eight-and-a-half-minute masterpiece was ranked number 5 among the 365 “most memorable” songs of the twentieth century. In 2002, the song was voted into the Grammy Hall of Fame. In 1997, Garth brooks performed “American (...) Pie” at a concert in Central Park, and in 2000, pop icon Madonna performed her own version of “American Pie” on the soundtrack of her movie The Next Best Thing. In 1999, American Pie became the title of a popular – and irreverently comical – coming-of-age movie starring Jason Biggs (the movie American Pie was followed by American Pie 2 in 2001, American Wedding in 2003, and American Pie Present – Band Camp in 2005). Like the movie to which it lent its name, the song “American Pie” presents a coming-of-age narrative; and, also like the movie, the song appealed strongly and immediately to its contemporary audience. Three months after its release in November of 1971, the song reached the number one slot on the charts in January of 1972, and it remained in the Top 40 for a total of seventeen weeks (longer than any other single during the year of 1972). Unlike the movie, however, the song “American Pie” is highly nuanced and sophisticated, containing multiple allusions and layers of meaning which challenge and heighten our understanding of rock ’n’ roll music and the possibility of self-reflection and self-critique in popular culture. (shrink)

This open access book presents a comparative study of two classics of world literature, offering the first sustained study of what unites and divides the Nicomachean Ethics and the Bhagavad Gita. -/- Asking what the texts think is the nature of moral action and how it relates to the highest good, Roopen Majithia shows how the Gita stresses the objectivity of knowledge and freedom from being a subject, while the Ethics emphasizes the knower, working out Aristotle’s central commitment to the (...) idea of substance as the primary building block of the world. Yet both the Gita and the Ethics explain variety in human behaviour in terms of three driving forces. Both agree moral agency is a construct that is a function of background, education and habit, presupposing a cultural, political and economic infrastructure. -/- What distinguishes the texts is how the content of right action is generated. Reading them together, alert to their individual accounts of how the practical relates to the reflective dimensions of life, Majithaia enriches our understanding of two cornerstone texts in the Greek and Indian philosophical traditions. -/- The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on bloomsburycollectionsdotcom. Open access was funded by The Marjorie Young Bell Faculty Fund and The Hart Almerrin Massey Endowment. (shrink)

A fundamental problem in understanding the nature of time is explaining its directionality. This 1990 PhD thesis re-examines the concepts of time flow, the physical directionality of time, and the semantics of tensed language. Several novel results are argued for that contradict the orthodox anti-realist views still dominant in the subject. Specifically, the concept of "metaphysical time flow" is supported as a valid scientific concept, and argued to be intrinsic to the directionality of objective probabilities in quantum mechanics; the common (...) claims that quantum probability theory is time reversible is shown to be based on an analytic error, stemming from a false choice for the criterion for reversibility of probabilistic theories (recognized by Satosi Watanabe in the 1950s but ignored in all philosophical discussions); and a consistent semantics for tensed language (adapted from the tree model of Storrs McCall) is constructed, showing that the common rejection of "time flow" as having no meaningful semantics is false. These debates are still ongoing in almost exactly the same state they were pre-1990, and there is appears to be no visible progress in the subject. Critical points made against errors in the orthodox account (which has been sustained for 70 years by the anti-realist philosophy of time, typified by the "Pittsburg School" of Grunbaum-Earman-Norton-Roberts), are still not recognized in the philosophy of time or physics. Some key technical proofs in this thesis have been published in physics proper. See p.ii-iii for full original abstract. (This pdf is uploaded from the Massey University archive.). (shrink)

In Part I of this essay I presented a general account of self-esteem, arguing that accounts which have previously been offered in the philosophical literature have been inadequate both in their analyses of the concept of self-esteem, and in their prescriptions for healthy self-esteem. More specifically, I argued that the analyses offered by Rawls, Sachs, Thomas, Deigh, Massey, and others are all versions of self-esteem based upon developed capacities, and that all such versions fail in one way or another (...) to meet three intuitive criteria for adequate self-esteem: roughly, that it be high, stable, and well-connected with other important human goods. In this Part II of the essay I present an account of optimal self-esteem--esteem based upon appreciation for what it is to be a human being-arguing that it is psychologically possible and that it measures up to the three criteria for adequacy. The strategy I will employ toward both of these goals is two-fold: first, to show how the sort of capacity-based esteem I criticized as inadequate in Part I can be modified to more closely meet the named criteria for adequacy; and second to show that the sort of self-esteem I will describe as optimal can be seen as a further stage in the development of this improved capacity-based variety. (shrink)