The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

Preface thoroughly outlines the development and status of dark matter theory at the time of publishing this book. First chapter is like a combat between mathematical counterintuitive physics and human commonsense and explains that human commonsense equipped with proper philosophical approach is capable to deal with the problem of dark matter. Thus the first chapter makes a case for human commonsense and philosophical method.

Preface thoroughly outlines the development and status of dark matter theory at the time of publishing this book. First chapter is like a combat between mathematical counterintuitive physics and human commonsense and explains that human commonsense equipped with proper philosophical approach is capable to deal with the problem of dark matter. Thus the first chapter makes a case for human commonsense and philosophical method.

Scientific inquiry takes onward course from the point where previous scientists had reached. But philosophical analysis initiates from scratch. Philosophy questions everything and chooses starting point for itself after having ruled out all the unsubstantiated and doubtful elements of the topic under study. Secondly, known realities must make sense. If a theory is officially 'counterintuitive', then either it is mere fiction or at the most; a distorted form of truth. This book's analysis is based on the philosophical principle that knowledge (...) is empirical and does not arise magically in absence of observational grounds. With philosophical approach, it was doubtful to accept that Georges Lemaître already knew Hubble's law in year 1927 that was yet to be found by Edwin Hubble in year 1929. Therefore this book started with denial of the claim that Lemaître already knew this law. But analysis of section I.III forced author to look the matter from original source and it came to surface that Lemaître knew this law in year 1927. But contrary to mainstream claim, Lemaître had not derived that law from general relativity (GR) equations rather had deduced from a method given by Hubble himself. Whereas whole case of the Big Bang Theory rests on misleading claim that Lemaître had derived this law solely from GR equations. The basis of this claim happened to be a manipulated translation (1931) of Lemaître's original 1927 article. People regard Big Bang Theory as truth because authoritative sources deceived them by presenting a manipulated translation in year 1931. This book is a philosophical analysis of original papers of Alexander Friedmann (1922), Georges Lemaître (1927), Edwin Hubble (1929) and Albert Einstein (1917) thus covers actual roots and origins of the Big Bang Model. In this book, only the core elements of the Big Bang Model i.e. 'Expansion of Universe' and 'CMBR' are covered. It has been sufficiently shown that 'expansion' is an illusion whereas CMBR is a proof that we live in a non-expanding infinite universe. If these two core elements of the standard Big Bang Model are precisely refuted then there is nothing crucial left with the standard model. For readers of this book at least, Big Bang Theory shall become a story of past mistakes. Author is not an authoritative source on science topics therefore readers must download all the above mentioned original papers and check all the points outlined in this book from relevant original papers. Unlike reading from an authoritative source that makes readers relaxed and careless but enables authorities to deceive them in worst way possible, this book requires readers to remain alert on all the points discussed in the book and verify everything from original sources whose links are given at the end of this description and also provided in footnotes section of the book. This book is not a judgment of the topic rather it is like a case presented by an advocate while readers are the judges. Readers are required to apply their own critical judgment to conclude the matter by themselves. After carefully reading this book, readers will also start taking 'authoritative sources' with due care and it will become difficult for the 'authorities' to deceive them again. (shrink)

Dark Matter was not matter at all. It was a theoretical brainteaser that finally philosophy had to unscramble. Scientists of today do not like this idea but philosophy is capable to deal with theoretical conundrums like dark matter. First chapter which is like a combat between mathematical counterintuitive physics and human commonsense, explains that human commonsense equipped with proper philosophical approach is capable to deal with the problem of dark matter. -/- After making a case for philosophical method, this book (...) then challenges the fundamental convictions of the established Cosmology and explains that even many visible galaxies are located at (light travel) distance of many hundred billion light years. There is no dark matter in any of the so-called 'proofs' of the existence of dark matter and MOND is also an engineered and artificial solution. -/- This book has solved Galactic Rotation problem using Newton's theory and have shown that available theory was capable to explain the flat rotation curves of galaxies without necessitating the existence of dark matter. Thus theory itself is not challenged, blamed or modified. However understanding of scientists of their so-called counterintuitive theories is blamed. For example, to deal with the Galactic Rotation problem, the relevant part of Newton's Principia Mathematica was Proposition LXXIII, Theorem XXXIII. Whereas to deal with this problem, scientists had wrongfully applied Proposition LXXI, Theorem XXXI. Obviously, inaccurate application of available theory resulted in a fake problem and dark matter only served as a ghost solution to that bogus problem. -/- Not only the Galactic Rotation, other so-called indicators of Dark Matter like Cluster Dynamics, Gravitational Lensing, Bullet Cluster, Dark Matter Ring, Fluctuations in CMB Temperature and Structures Formation etc. also have been explained without requiring the need for Dark Matter. -/- Overall this book has presented a strong case of the failure of counterintuitive regime of established Cosmology and Physics. (shrink)

The concept of a hypersoft membership function is introduced in the extension of a soft set known as a hypersoft set, permitting it to handle complicated and uncertain information in a more powerful and flexible manner. Many academics have already become fascinated with this new area of study, leading to the development of a number of hybrid structures. This chapter develops some new hybrid hypersoft set structures by taking into account multiple fuzzy set-like settings and possibility degree-based settings collectively. Additionally, (...) numerical examples are included to clarify the concept of these structures. Researchers can utilize this work to better understand and apply a variety of mathematical ideas. (shrink)