Abstract: This study explores some theoretical issues in scientific research such as, the nature of experimentation and problems of methodology in scientific practice as well as the question of truth, rationality, objectivity and utility of scientific discoveries. The paper discusses a number of theorizing that have emerged in response to the challenge raised by the above concerns. Epistemological models of science from critical rationalists, like Popper, Kuhn, Feyerabend and the neo-pragmatic methodological orientation of Arthur Fine’s Natural Ontological (...) class='Hi'>Attitude (NOA) to Science, have been adopted as points of discussion on what science as an empirical discipline entail. The paper concludes that a rigorous epistemological discussion on the methodology of scientific inquiry is a desideratum for the progress of science. (shrink)