Objective: to evaluate CANLPH score and systemic immune inflammation index (SII) in patients with symptomatic rheumatic mitral stenosis (MS) undergoing percutaneous mitral balloon valvuloplasty (PMBV). -/- Methods: 62 patients who underwent PMBV in our clinic between 2018 and 2021 were included retrospectively. The patients were divided into 2 groups according to echo score. The CANLPH score was calculated from the cut-off values of C-reactive protein to albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR) and platelet to hemoglobin ratio (PHR), determined (...) with the Youden index and SII by the formula platelet x neutrophil/lymphocyte. P <0.05 was considered statistically significant. -/- Results: The mean age of the patients was 44.5±10.4 years (40 female, 64.5%). The mean values of SII and CANLPH scores were higher in the Echo score >8 group (p <0.001, both). The mean mitral gradient before and after PMBV was 12.6±5.7mm Hg and 5.0±2.4 mm Hg, and the mean valve area was 1.12±0.27 cm2 and 1.85±0.29 cm2. A statistically significant and negative correlation was observed between the gradient decrease after the procedure and the CANLPH score and SII (r=-0.426, p=0.001 and r=-0.418, p=0.001, respectively). In receiver operating characteristic (ROC) curve analysis, it was concluded that the ability of CANPLH score to predict the higher Echo scores was noninferior to SII with an area under curve (AUC:0.820 (0.701-0.906) and AUC:0.786 (0.664-0.880), z statistics 0.576 and p=0.564. -/- Conclusion: SII and CANLPH scores are correlated with Echo score. A significant negative relationship was found with both biomarkers and gradient decrease after the PMBV. (shrink)

Molla Lutfī of Tokat is one of the fifteenth-century Ottoman scholars. His work “Risālah (Kalimāt) Muta'alliqah bi Ayah al- Ḥajj” covers many jurisprudential issues about al- Ḥajj (pilgrimage). In the mentioned work, he criticized the interpretation for the verses 196-198 of surah al Baqarah in the book “al-Kashshāf 'an Haqā'iq Ghawāmid al- Tanzīl wa 'Uyūn al-Aqāwīl fī Wujūh al-Ta'wīl” which is written predominantly in dirāyah method by the Mu’tazilī scholar al-Zamakhsharī, and the commentaries and annotations written on this interpretation. This (...) study discusses the conditions of Ḥajj, the isssue whether the ʿUmrah is wajib or not, abrogation of an āyah by an hadith, the time for three days fasting during Ḥajj, certain times for performing the rituals of Ḥajj, the issue whether the waqfa on Arafah is wajib or not, and also Molla Lutfi’s views and objections on these topics. (shrink)