The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

Socio-Economic Impacts of Co-operative Societies: An Empirical Study -/- Author / Authors :Md. Ruhul Amin and Mohammed Mahin Uddin Page no.179-193 Discipline : Applied Economics/ Management/ Commerce Script/language : English/Roman Category : Research paper Keywords: Co-operative, Development, Society, Constrains, Constitution, Comilla.

This paper examines the innovative application of Artificial Intelligence (AI) to simulate real-time historical what-if scenarios, exploring its potential for creating immersive and engaging educational experiences. AI-driven simulations could revolutionize the way history is taught, allowing users to engage directly with alternative historical outcomes. By exploring possible scenarios—such as different outcomes for major events like World War II or the Cuban Missile Crisis—students and educators can gain deeper insights into historical processes. This paper discusses the methodologies behind AI-driven historical simulations, (...) the technical and ethical challenges involved, and the future potential of this technology. (shrink)

The ancient names of Assam were Kamrupa and Pragjyotisa, which had been inhabited by the Kirata or Mongoloid people before the Aryan culture could spread its influence over the North Eastern part of India. Before the advent of the Aryan civilization, the Austric-Mongolian and Dravidian culture was the prevalent culture of the people of this area. According to some scholar, the Aryans advent in North East India was occurrence of the pre-Buddhist period. The period of the Brahmins was followed by (...) the Buddhist period, so far as the cultural history of India is concerned. In comparatively, ancient inscriptions of Assam, we find that, the high caste Aryans like Brahmans, Shatriyas and Kalitas entered into Assam and began to settle here even during the Pre-Christian era. The mention of Kamrupa and Devoka in the Allahabad pillar inscription of the Gupta king Samudragupta has an important bearing on the Aryanisation of North East India. In the domain of political system, it is all probable that the ancient Assam populated by the non-Khmer group of the Austric and the Tibeto-Burman people was in tribal state of society. Narakasura and Bhagadutta, the legendary kings of Assam were probably the first monarchical rulers and they were in all probability the Aryanised or Hunduised Mongoloid persons. In other words, the tribal political system of Assam was changed into monarchical system by the influence of the Aryan culture. (shrink)

In this thirteenth book of scilogs – one may find topics on Neutrosophy, Plithogeny, Physics, Mathematics, Philosophy – email messages to research colleagues, or replies, notes, comments, remarks about authors, articles, or books, spontaneous ideas, and so on. It presents new types of soft sets and new types of topologies. -/- Exchanging ideas with Mohammad Abobala, Ishfaq Ahmad, Ibrahim M. Almanjahie, Fatimah Alshahrani, Nizar Altounji, Muhammad Aslam, Said Broumi, Victor Christianto, R. Diksh, Feng Liu, Frank Julian Gelli, Erick Gonzalez Caballero, (...) Riad Hamido, Yaser Al-Hasan, Ahmed Hatip, Yasin Karmouta, Nivetha Martin, Preda Mihăilescu, V. Lakshmana Gomathi Nayagam, Ze Carlos Tiago de Oliveira, Alexey Platonov, Andrei Pogany, Shakti Prasad, Ranulfo Paiva Barbosa (Sobrinho), Dmitri Rabounski, Ackbar Rezaei, Constantin Sandu, A. Saraswathi, Usman Shahzad, Gocho V. Sharlanov, Stefan Spaarmann, Michael Voskoglou, Vinay Kumar Yadav, Tomasz Witczak, William H. Woodall, Mircea Zărnescu, Mohamed Bisher Zeina (in order of reference in the book). (shrink)