The principles of the 3Rs—replacement, refinement, and reduction—strongly shape discussion of methods for performing more humane animal research and the regulation of this contested area of technoscience. This special issue looks back to the origins of the 3Rs principles through five papers that explore how it is enacted and challenged in practice and that develop critical considerations about its future. Three themes connect the papers in this special issue. These are the multiplicity of roles enacted by those who use and (...) care for animals in research, the distribution of “feelings that matter” across species and spaces of laboratory animal practice, and the growing importance of “cultures of care” in animal research. (shrink)

In this commentary, Kristin Asdal reflects on pragmatism as one of the methodological touchstones of Science, technology and society. In its focus on practices, pragmatist STS can be prone to falling into a problematic presentism, obscuring the historicity of the practices being studied, and to falling into problematic material/semiotic binaries. But what does it take, in practice, to be pragmatic? In her commentary, Asdal points to how this ought to imply being open when it comes to our choice of methods, (...) thus finding creative ways of maintaining a crucial recognition of history as well as relations between the textual and the material. This in turn might instantiate new, distinctive, and inspiring modes of pragmatist methodological insight—such as precisely in these special issue papers devoted to animal care. These papers are also inspiringly pragmatic, in the meaning of careful—in order not to be overtly programmatic, i.e. deciding beforehand your position or standpoint on a given topic, such as human–animal relations. Following on from this she puts forward the notion “interested methods.”. (shrink)

Most children and families have not had direct contact with child psychological and psychiatric experts. Instead they encounter developmental theories, etiological explanations and depictions of childhood disorders through indirect channels such as newspapers. Drawing on actor–network theory, this article explores two child psychological and psychiatric modes of ordering children’s mental health discernible in Sweden’s largest morning newspaper, Dagens Nyheter, during the years 1980 to 2008: a psychodynamic mode and a neuro-centered mode. In the article I show how these two relatively (...) contemporaneous modes greatly differed in how they enacted children’s mental health. The psychodynamic mode stressed the parents’ role in structuring and affecting the child’s unconscious and saw them as the primary cause of any mental illness. In contrast, the neuro-centered mode highlighted that mental issues were related to the child’s brain and proposed different solutions depending on whether the child’s brain functioned in a ‘normal’ or ‘atypical’ manner. Each mode moreover suggested differing contexts to their discussions, with the psychodynamic mode solely discussing the parental milieu while the neuro-centered mode mainly focused on how society affected children with ‘atypical’ brains. The two modes thus had significantly diverging implications for the reader on how to understand and manage children and their psychological well-being. I further argue in the article for the relevance of actor–network theory in historical studies of psychology and psychiatry. (shrink)

Given their commitment to practices, science studies have bestowed considerable attention upon objects. We have the boundary object, the standardized package, the network object, the immutable mobile, the fluid object, even a fire object has entered the scene. However, these objects do not provide us with a way of understanding their historicity. They are timeless, motionless pictures rather than things that change over time, and while enacting ‘historical moments’ they do not make visible the histories they contain within them. What (...) kind of object could embody history and make that history visible? Inspired by Michel Serres, I suggest the folded object is a way to attend to the temporality and spatiality of objects. In this article I explore this new object by unravelling the history of a DNA reference sequence. I show how, ever since it was produced in the early 1980s, attempts have been made to filter race out of the sequence. That effort has failed due to what one could call ‘political noise’. Making and remaking the sequence have left traces that cannot be erased. (shrink)

The 3Rs, or the replacement, reduction, and refinement of animal research, are widely accepted as the best approach to maximizing high-quality science while ensuring the highest standard of ethical consideration is applied in regulating the use of animals in scientific procedures. This contrasts with the muted scientific interest in the 3Rs when they were first proposed in The Principles of Humane Experimental Technique. Indeed, the relative success of the 3Rs has done little to encourage engagement with their original text, which (...) remains little read and out of print. By adopting a historical perspective, this article argues that one explanation for this disjunction may be found in another, more celebrated, event of 1959: C. P. Snow’s Rede lecture on The Two Cultures. The moral outlook of The Principles of Humane Experimental Technique derived from an earlier ethos wherein humanistic and scientific values occupied a shared culture. While the synthetic style of The Principles has hindered its readership, this article concludes that there is value to recovering the notion that the humanities and social sciences can contribute to the improvement of animal research. (shrink)

ArgumentThis article adopts a historical perspective to examine the development of Laboratory Animal Science and Medicine, an auxiliary field which formed to facilitate the work of the biomedical sciences by systematically improving laboratory animal production, provision, and maintenance in the post Second World War period. We investigate how Laboratory Animal Science and Medicine co-developed at the local level (responding to national needs and concerns) yet was simultaneously transnational in orientation (responding to the scientific need that knowledge, practices, objects and animals (...) circulate freely). Adapting the work of Tsing (2004), we argue that national differences provided the creative “friction” that helped drive the formation of Laboratory Animal Science and Medicine as a transnational endeavor. Our analysis engages with the themes of this special issue by focusing on the development of Laboratory Animal Science and Medicine in Norway, which both informed wider transnational developments and was formed by them. We show that Laboratory Animal Science and Medicine can only be properly understood from a spatial perspective; whilst it developed and was structured through national “centers,” its orientation was transnational necessitating international networks through which knowledge, practice, technologies, and animals circulated. (shrink)

The use of nonhuman animals as models in research and drug testing is a key route through which contemporary scientific knowledge is certified. Given ethical concerns, regulation of animal research promotes the use of less “sentient” animals. This paper draws on a documentary analysis of legal documents and qualitative interviews with Named Veterinary Surgeons and others at a commercial laboratory in the UK. Its key claim is that the concept of animal sentience is entangled with a particular imaginary of how (...) the general public or wider society views animals. We call this imaginary societal sentience. Against a backdrop of increasing ethnographic work on care encounters in the laboratory, this concept helps to stress the wider context within which such encounters take place. We conclude that societal sentience has potential purchase beyond the animal research field, in helping to highlight the affective dimension of public imaginaries and their ethical consequences. Researching and critiquing societal sentience, we argue, may ultimately have more impact on the fate of humans and nonhumans in the laboratory than focusing wholly on ethics as situated practice. (shrink)

This paper advances two arguments about environmental problems. First, it interrogates the strength and limitations of empiricist accounts of problems and issues offered by actor-network theory. Drawing on the work of C.S. Peirce, it considers how emerging environmental problems often lead to abductive inferences about the existence of hidden causes that may or may not have caused the problem to emerge. The analysis of environmental problems should be empiricist in so far as it is sceptical of the claims of those (...) who know in advance what the problem is, but it should also be alert to processes and things that are not readily traceable or perceived. Secondly, the paper’s contention is that environmental problems almost invariably involve an encounter between unlike or disparate materials or processes. In such circumstances, the challenge is to develop a form of inquiry that is alert to both the specificity of such encounters and to the specificity of the political situations in which they come to matter. (shrink)

ArgumentAt the turn of the twentieth century the Norwegian market flourished with milk products intended for infants. But medical doctors argued in favor of “going back to nature”: Women ought to breastfeed their children. This paper explores how a re-naturalization of mother's milk emerged within experimental medicine. The prescribed “natural way” did not develop within medicine alone. The paper demonstrates how the natural developed within a relational space of different versions of milk: the free-market milk, the dirty and decaying milk, (...) and the non-nutritional milk. But why did Norwegian mothers, in contrast to the development in for instance the US, continue to breastfeed their infants? Drawing on the work of the leading pediatrician Theodor Frølich, the paper suggests that this may in part be explained by the development of a distinct version of care: A matter-of-fact, pragmatic and flexible version of care that nevertheless came to enact mother's milk as the supreme form of nutrition to which there was hardly a competing or healthy alternative. “The natural way” became a thought style and was made integral to everyday culture. (shrink)