I argue that there is nothing about the structure of inference to the best explanation (IBE) that prevents it from establishing a contradiction in general, though there are some potential limitations on when it can be used for this purpose. Studying the relationship between IBE and contradictions is worthwhile for three reasons. First, it enhances our understanding of IBE. We see that, in many cases, IBE does not require explanations to be consistent, though there are some cases where consistency may (...) be required. Second, the argument has implications for the debate over scientific realism. Many scientific theories appear to be inconsistent. The best argument for scientific realism, however, appeals to IBE. My argument thus shows that a certain kind of realist faces a threat from inconsistent theories. Third, the argument is important for dialetheism. Dialetheists maintain that some contradictions are true. Many of the arguments in favour of dialetheism appeal to explanatory considerations. What I say here provides support for defending dialethism using an IBE-based methodology. (shrink)