The Institutional Animal Care and Use Committee is entrusted with assessing the ethics of proposed projects prior to approval of animal research. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, and Refinement. However, these principles are poorly defined. Although this provides the IACUC leeway in assessing a proposed project, it also affords little guidance. Our goal is to provide procedural and philosophical clarity (...) to the IACUC without mandating a particular outcome. To do this, we analyze the underlying logic of the Three Rs and conclude that the Three Rs accord animals moral standing, though not necessarily “rights” in the philosophical sense. We suggest that the Rs are hierarchical, such that Replacement, which can totally eliminate harm, should be considered prior to Reduction, which decreases the number of animals harmed, with Refinement being considered last. We also identify the need for a hitherto implicit fourth R: Reject, which allows the IACUC to refuse permission for a project which does not promise sufficient benefit to offset the pain and distress likely to be caused by the proposed research. (shrink)

Societal and technological development during the last century has enabled Western economies to achieve a high standard of living. Yet this profusion of wealth has led to several outcomes that are undesirable and/or unsustainable. There is thus an imperative need for a fundamental and rapid transition towards more sustainable practices. While broad conceptual frameworks for managing sustainability transitions have been suggested in prior literature, these need to be further developed to suit contexts in which the overall vision is arguably clear, (...) such as in the case of consuming animal-originated foodstuffs. In this article we introduce a novel transition management framework that is based upon the dimensions of sustainability. The suggested transition management process includes the identification of objectives and obstacles, the listing of options and their opportunities and threats as well as the evaluation of the outcomes (the Five O’s). We argue that sustainability transition management should be a process in which the identification of the relevant dimensions of sustainability and related objectives forms the foundation for strategic, tactical and operational governance activities. We illustrate the practical applicability of the framework in the case of transition towards plant-based diets. (shrink)