This paper attempts to trace part of the history of medical and philosophical exchanges within the materialist tradition. I focus on this decisive role that they play on the emergence of organismic conception of the body. From its very beginnings, medical thought as the thought of mixture and as psychophysiology has been in close connection with the pre-Socratic tradition, and with Empedocles in particular. Both of them propose accounts of the blending as protoconceptions of an organic model of the body. (...) In the regard, the Stoic conception of krasis and the new model of the organismic individuality that it defines indebt to this medical and philosophical account. In this regard, the Galenic thought of mixture as an immanent and dynamic unity is also part of this materialistic and corporeist tradition. Within it, individual identity is conceived as fundamentally relational. It benefits from an undeniable Stoic account, while giving it an unprecedented medical extension. (shrink)