In this article I analyse some moments of Nietzsche’s reception and influence between Europe and America (namely in Martin Heidegger, Giovanni Papini and Josiah Royce) from a pragmatist perspective, in order to show how a selective monism and a realist pluralism emerge from their interpretations of Nietzsche. On the basis of this historiographic and theoretical reconstruction, I emphasize that Nietzsche, through both his monism and his pluralism, can question any presumed irreversibility in the moral field. By recognising the subject’s possibility (...) of change, of reversing the only superficial irreversibility of its Da-sein, Nietzsche’s pragmatism in this sense represents a great theoretical achievement, indispensable for the definition of a new bio-anthropological paradigm, in which identity can effectively coexist with difference. (shrink)