We carried out a systematic review of psycholinguistic, empirical, quantitative studies on verbal irony use and individual differences (i.e. psychological, not demographic, traits that significantly differentiate individuals). Out of 5,967 publications screened, 29, comprising 35 studies in total, were included. Following a qualitative content analysis, six thematic clusters were identified, representing areas of research in individual differences in irony use: (a) psychological well-being, (b) personality traits, (c) humor-related traits, (d) cultural factors, (e) social skills, and (f) cognitive factors. The results (...) of the studies in each cluster are summarized and conclusions for further research are presented. In particular, the systematic review suggests that irony and sarcasm should be clearly delineated as separate, yet related phenomena due to differing patterns of correlations with specific individual differences. Additionally, significant methodological heterogeneity between the studies suggests the need for greater standardization of irony use measures. (shrink)