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The Product Guides the Process: Discovering Disease Mechanisms

In David Danks & Emiliano Ippoliti (eds.), Building Theories: Heuristics and Hypotheses in Sciences. Cham: Springer International Publishing (2018)

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  1. Race and medicine in light of the new mechanistic philosophy of science.Kalewold Hailu Kalewold - 2020 - Biology and Philosophy 35 (4):1-22.
    Racial disparities in health outcomes have recently become a flashpoint in the debate about the value of race as a biological concept. What role, if any, race has in the etiology of disease is a philosophically and scientifically contested topic. In this article, I expand on the insights of the new mechanistic philosophy of science to defend a mechanism discovery approach to investigating epidemiological racial disparities. The mechanism discovery approach has explanatory virtues lacking in the populational approach typically employed in (...)
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  • Binding Specificity and Causal Selection in Drug Design.Oliver M. Lean - 2020 - Philosophy of Science 87 (1):70-90.
    Binding specificity is a centrally important concept in molecular biology, yet it has received little philosophical attention. Here I aim to remedy this by analyzing binding specificity as a causal property. I focus on the concept’s role in drug design, where it is highly prized and hence directly studied. From a causal perspective, understanding why binding specificity is a valuable property of drugs contributes to an understanding of causal selection—of how and why scientists distinguish between causes, not just causes from (...)
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  • Molecular pathways and the contextual explanation of molecular functions.Giovanni Boniolo & Raffaella Campaner - 2018 - Biology and Philosophy 33 (3-4):24.
    Much of the recent philosophical debate on causation and causal explanation in the biological and biomedical sciences has focused on the notion of mechanism. Mechanisms, their nature and epistemic roles have been tackled by a range of so-called neo-mechanistic theories, and widely discussed. Without denying the merits of this approach, our paper aims to show how lately it has failed to give proper credit to processes, which are central to the field, especially of contemporary molecular biology. Processes can be summed (...)
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