The mantra that "the best way to predict the future is to invent it" (attributed to the computer scientist Alan Kay) exemplifies some of the expectations from the technical and innovative sides of biomedical research at present. However, for technical advancements to make real impacts both on patient health and genuine scientific understanding, quite a number of lingering challenges facing the entire spectrum from protein biology all the way to randomized controlled trials should start to be overcome. The proposal in (...) this chapter is that philosophy is essential in this process. By reviewing select examples from the history of science and philosophy, disciplines which were indistinguishable until the mid-nineteenth century, I argue that progress toward the many impasses in biomedicine can be achieved by emphasizing theoretical work (in the true sense of the word 'theory') as a vital foundation for experimental biology. Furthermore, a philosophical biology program that could provide a framework for theoretical investigations is outlined. (shrink)

In de Ronde and Massri it was argued against the orthodox definition of quantum entanglement in terms of pure and separable states. In this paper we attempt to discuss how the logos categorical approach to quantum mechanics is able to provide an objective formal account of the notion of entanglement—completely independent of both purity and separability—in terms of the potential coding of intensive relations and effective relations. We will show how our novel redefinition allows us to provide an anschaulich content (...) to the notion of entanglement, erasing in this way the “spookiness” still present within its orthodox understanding in terms of space-time separated collapse particles. (shrink)

The article is devoted to the problem of interpreting of the several consequences that derive from multi-world concepts of modern physics. The inflation scenario and the associated string landscape model are the objects of analysis. The reviewed multi-world concepts are exposed to presume the existence of a plenitude of various fundamental principles that govern the physics of one or another possible reality. The research is based on the hermeneutical method, comparative method, dialectical method, formal translation method, and scientific modeling method. (...) The author represents specifics of physical theories that claim to describe all possible worlds in the conclusions. In this regard, the issues of the status of “possible” and “impossible” worlds and practicable ways to determine them are discussed. The main result of the study is the justification that each type of world must correspond to a certain structure of consciousness defined by its basic physical principles. This possibly means that a unified “theory of everything” that includes all possible mathematical and physical fundamental structures cannot exist since every one of them determines a specific type of consciousness. (shrink)

Advances in biology, at least over the past two centuries, have mostly relied on theories that were subsequently revised, expanded or eventually refuted using experimental and other means. The field of theoretical biology used to primarily provide a basis, similar to theoretical physics in the physical sciences, to rationally examine the frameworks within which biological experiments were carried out and to shed light on overlooked gaps in understanding. Today, however, theoretical biology has generally become synonymous with computational and mathematical biology. (...) This could in part be explained by a relatively recent tendency in which a "data first", rather than a "theory first", approach is preferred. Moreover, generating hypotheses has at times become procedural rather than theoretical, therefore perhaps inadvertently leading some hypotheses to become perfunctory in nature. This situation leaves our understanding enmeshed in data, which should be disentangled from much noise. Given the many unresolved questions in biology and medicine, big and small, ranging from the problem of protein folding to unifying causative frameworks of complex non-Mendelian human diseases, it seems apt to revive the role of pure theory in the biological sciences. This paper, using the current biomedical literature and historical precedents, makes the case for a "philosophical biology" (philbiology), distinct from but quite complementary to philosophy of biology (philobiology), which would entail biological investigation through philosophical approaches. Philbiology would thus be a reincarnation of theoretical biology, adopting the true sense of the word "theory" and making use of a rich tradition of serious philosophical approaches in the natural sciences. A philbiological investigation, after clearly defining a given biological problem, would aim to propose a set of empirical questions, along with a class of possible solutions, about that problem. Importantly, whether or not the questions can be tested using current experimental paradigms would be secondary to whether the questions are inherently empirical or not. These issues will be illustrated using a range of specific examples. The final goal of a philbiological investigation would be to develop a theoretical framework that can lead observational and/or interventional experimental studies of the defined problem, a framework that is structured, generative and expandable, and, crucially, one that simplifies some aspect(s) of the said problem. (shrink)

We defend the many-worlds interpretation of quantum mechanics against the objection that it cannot explain why measurement outcomes are predicted by the Born probability rule. We understand quantum probabilities in terms of an observer's self-location probabilities. We formulate a probability postulate for the MWI: the probability of self-location in a world with a given set of outcomes is the absolute square of that world's amplitude. We provide a proof of this postulate, which assumes the quantum formalism and two principles concerning (...) symmetry and locality. We also show how a structurally similar proof of the Born rule is available for collapse theories. We conclude by comparing our account to the recent account offered by Sebens and Carroll. (shrink)

The article is devoted to the problem of interpreting of the several consequences that derive from multi-world concepts of modern physics. The inflation scenario and the associated string landscape model are the objects of analysis. The reviewed multi-world concepts are exposed to presume the existence of a plenitude (possibly infinite) of various fundamental principles (laws of nature) that govern the physics of one or another possible reality. The research is based on the hermeneutical method, comparative method, dialectical method, formal translation (...) method, and scientific modeling method. The author represents specifics of physical theories (the criteria and requirements for them) that claim to describe all possible worlds in the conclusions. In this regard, the issues of the status of “possible” and “impossible” worlds and practicable ways to determine them are discussed. The main result of the study is the justification (based on the assumption of many fundamentally different worlds scenario possibility) that each type of world must correspond to a certain structure of consciousness defined by its basic physical principles (and probably other mathematics). This possibly means that a unified “theory of everything” that includes all possible mathematical and physical fundamental structures cannot exist since every one of them determines a specific type of consciousness (where it is possible). (shrink)

The experimental research paradigm lies at the core of empirical psychology. New data analytical and computational tools continually enrich its methodological arsenal, while the paradigm’s mission remains the testing of theoretical predictions and causal explanations. Predictions regarding experimental results necessarily point to the future. Once the data are collected, the causal inferences refer to a hypothesis now lying in the past. The experimental paradigm is not designed to permit strong inferences about particular incidents that occurred before predictions were made. In (...) contrast, historical research and scholarship in other humanities focus on this backward direction of inference. The disconnect between forward-looking experimental psychology and backward-looking historical (i.e., narrative) psychology is a challenge in the postmodern era, which can be addressed. To illustrate this possibility, I discuss three historical case studies in light of theory and research in contemporary psychology. (shrink)

The Everett interpretation of quantum mechanics divides naturally into two parts: first, the interpretation of the structure of the quantum state, in terms of branching, and second, the interpretation of this branching structure in terms of probability. This is the second of two reviews of the Everett interpretation, and focuses on probability. Branching processes are identified as chance processes, and the squares of branch amplitudes are chances. Since branching is emergent, physical probability is emergent as well.

I raise some problems for David Deutsch's (2016) attempt to develop a confirmation theory for branching worlds.

In this paper we consider the notion of quantum entanglement from the perspective of the logos categorical approach [26, 27]. Firstly, we will argue that the widespread distinctions, on the one hand, between pure states and mixed states, and on the other, between separable states and entangled states, are completely superfluous when considering the orthodox mathematical formalism of QM. We will then argue that the introduction of these distinctions within the theory of quanta is due to another two completely unjustified (...) metaphysical presuppositions, namely, the idea that there is a “collapse” of quantum states when being measured and the idea that QM talks about “elementary particles”. At distance from these distinctions and taking the logos approach as a standpoint, we will propose an objective formal account of the notion of entanglement in terms of potential coding which introduces the necessary distinction between intensive relations and effective relations. We will also discuss how this new definition of entanglement provides an anschaulich content to this —supposedly “spooky”— quantum relational feature. (shrink)