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  1. Ethical issues surrounding controlled human infection challenge studies in endemic low‐and middle‐income countries.Euzebiusz Jamrozik & Michael J. Selgelid - 2020 - Bioethics 34 (8):797-808.
    Controlled human infection challenge studies (CHIs) involve intentionally exposing research participants to, and/or thereby infecting them with, micro‐organisms. There have been increased calls for more CHIs to be conducted in low‐ and middle‐income countries (LMICs) where many relevant diseases are endemic. This article is based on a research project that identified and analyzed ethical and regulatory issues related to endemic LMIC CHIs via (a) a review of relevant literature and (b) qualitative interviews involving 45 scientists and ethicists with relevant expertise. (...)
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  • Human infection challenge studies in endemic settings and/or low-income and middle-income countries: key points of ethical consensus and controversy.Euzebiusz Jamrozik & Michael J. Selgelid - 2020 - Journal of Medical Ethics 46 (9):601-609.
    Human infection challenge studies (HCS) involve intentionally infecting research participants with pathogens (or other micro-organisms). There have been recent calls for more HCS to be conducted in low-income and middle-income countries (LMICs), where many relevant diseases are endemic. HCS in general, and HCS in LMICs in particular, raise numerous ethical issues. This paper summarises the findings of a project that explored ethical and regulatory issues related to LMIC HCS via (i) a review of relevant literature and (ii) 45 qualitative interviews (...)
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