The paper presents a detailed interpretation of Edgar Wind’s Experiment and Metaphysics, a unique work on the philosophy of physics which broke with the Neo-Kantian tradition under the influence of American pragmatism. Taking up Cassirer’s interpretation of physics, Wind develops a holistic theory of the experiment and a constructivist account of empirical facts. Based on the concept of embodiment which plays a key role in Wind’s later writings on art history, he argues, however, that the outcomes of measurements are contingent. (...) He then proposes an anti-Kantian conception of a metaphysics of nature. For him, nature is an unknown totality which manifests itself in discrepancies between theories and experiment, and hence the theory formation of physics can increasingly approximate the structure of nature. It is shown that this view is ambiguous between a transcendental, metaphysical realism in Kant’s sense and an internal realism in Putnam’s sense. Wind’s central claim is that twentieth century physics offers new options for resolving Kant’s cosmological antinomies. In particular, he connected quantum indeterminism with the possibility of human freedom, a connection that Cassirer sharply opposed. (shrink)