Sir Thomas Browne's reflection on the synthesis between his Christian religion and his practice as a medical doctor, made over three centuries ago, leads into reflections on the present relation between religion and science in the personal experience of the writer. An account is given of how the actual practice of scientific investigation led the author to theistic inferences and how the study of DNA provoked questions concerning reductionism and emergence. This evoked the need for a map of knowledge, and (...) an attempt is presented in a figure which also serves to clarify what kind of realistic reference is involved in both scientific and humanistic contexts–especially with respect to personal language. Theological investigations thereby receive at least provisional legitimization and, with this encouragement, the article pursues the questions of the nature of the divine Source (“God”) of the world's being and becoming, of God's interaction and communication with the world, especially with human beings in that world. The penultimate section outlines why the writer considers an explicit communication from God to humanity in Jesus of Nazareth is coherent with the foregoing and what this implies for human fulfillment, individually and corporately. The article concludes with a plea for humility before God and nature in our inquiries in the spirit both of Sir Thomas Browne and of the arch “agnostic” T. H. Huxley. (shrink)