Medicine in a Neurocentric World: About the Explanatory Power of Neuroscientific Models in Medical Research and Practice Content Type Journal Article Category Editorial Notes Pages 307-313 DOI 10.1007/s12376-009-0036-2 Authors Lara Huber, University Medical Center of the Johannes Gutenberg University Mainz Institute for History, Philosophy and Ethics of Medicine Am Pulverturm 13 55131 Mainz Germany Lara K. Kutschenko, University Medical Center of the Johannes Gutenberg University Mainz Institute for History, Philosophy and Ethics of Medicine Am Pulverturm 13 55131 Mainz Germany Journal (...) Medicine Studies Online ISSN 1876-4541 Print ISSN 1876-4533 Journal Volume Volume 1 Journal Issue Volume 1, Number 4. (shrink)

Traditionally, discussion about neuroimaging focuses on methodological improvement and neurobiological findings. In current psychiatric neuroimaging, the research focus broadens and includes concepts such as the self, personality, well-being, and psychiatric disease. This calls for the inclusion of disciplines like psychology and philosophy in a dialogue with neuroscience. Furthermore, it raises the question of how theories from these areas relate to neuroimaging findings: are results generated by objective data independent of theories? Is there an epistemological priority for the theories used for (...) generating hypotheses and for interpreting the results? Or do theoretical concepts and neuroimaging data influence each other? In this paper, we will discuss these positions concerning the priority of concepts and data in neuroimaging and provide arguments for an interdependence of concepts and data. An awareness of these considerations may help professionals from the life sciences and humanities as well as laypersons to avoid misunderstandings and oversimplifications. (shrink)

Medical expertise plays a major role in large-scale welfare arrangements, for example, in private insurance companies. It symbolizes the objectivity and reliability of the procedures of risk selection and legitimates the acceptance and rejection of clients. To understand "reliability" in this context, this article discusses the introduction of chemical urine analysis for life insurance examination between 1880 and 1920. The article argues that reliability of urine analysis is not an intrinsic characteristic of the technology and thus cannot serve as the (...) explanation for the relevance of this technology as a means of risk selection. The construction of a "reliable technology" went hand in hand with the development of a standardized, uniform, and predictable performance of the test and an emergence of specific network—namely, a large-scale, bureaucratic insurance practice in which examination rooms of physicians became connected to the head offices of insurance companies by administrative means. During this process, the balance of power between medical examiners and insurance companies was reversed. Insurance compa nies depended on medicine for risk selection, but physicians increasingly had to act according to the rules set by life insurance companies. (shrink)

This paper deals with Ludwik Fleck’s theory of thought styles and Michael Polanyi’s theory of tacit knowledge. Though both concepts have been very influential for science studies in general, and both have been subject to numerous interpretations, their accounts have, somewhat surprisingly, hardly been comparatively analyzed. Both Fleck and Polanyi relied on the physiology and psychology of the senses in order to show that scientific knowledge follows less the path of logical principles than the path of accepting or rejecting specific (...) conventions, where these may be psychologically or sociologically grounded. It is my aim to show that similarities and differences between Fleck and Polanyi are to be seen in the specific historical and political context in which they worked. Both authors, I shall argue, emphasized the relevance of perception in close connection to their respective understanding of science, freedom, and democracy. (shrink)

In the context of 1960s research on biological membranes, scientists stumbled upon a curiously coloured material substance, which became called the “purple membrane.” Interactions with the material as well as chemical analyses led to the conclusion that the microbial membrane contained a photoactive molecule similar to rhodopsin, the light receptor of animals’ retinae. Until 1975, the find led to the formation of novel objects in science, and subsequently to the development of a field in the molecular life sciences that comprised (...) biophysics, bioenergetics as well as membrane and structural biology. Furthermore, the purple membrane and bacteriorhodopsin, as the photoactive membrane transport protein was baptized, inspired attempts at hybrid bio-optical engineering throughout the 1980s. A central motif of the research field was the identification of a functional biological structure, such as a membrane, with a reactive material substance that could be easily prepared and manipulated. Building on this premise, early purple membrane research will be taken as a case in point to understand the appearance and transformation of objects in science through work with material substances. Here, the role played by a perceptible material and its spontaneous change of colour, or reactivity, casts a different light on objects and experimental practices in the late twentieth century molecular life sciences. With respect to the impact of chemical working and thinking, the purple membrane and rhodopsins represent an influential domain straddling the life and chemical sciences as well as bio- and material technologies, which has received only little historical and philosophical attention. Re-drawing the boundary between the living and the non-enlivened, these researches explain and model organismic activity through the reactivity of macromolecular structures, and thus palpable material substances. (shrink)

Microbial diversity has become a leitmotiv of contemporary microbiology, as epitomized in the concept of the microbiome, with significant consequences for the classification of microbes. In this paper, I contrast microbiology’s current diversity ideal with its influential predecessor in the twentieth century, that of purity, as epitomized in Robert Koch’s bacteriological culture methods. Purity and diversity, the two polar opposites with regard to making sense of the microbial world, have been operationalized in microbiological practice by tools such as the “clean” (...) Petri dish versus the “dirty” Winogradsky column, the latter a container that mimics, in the laboratory, the natural environment that teems with diverse microbial life. By tracing the impact of the practices and concepts of purity and diversity on microbial classification through a history of techniques, tools, and manuals, I show the shifts in these concepts over the last century. Juxtaposing the dominant purity ideal with the more restricted, but continuously articulated, diversity ideal in microbial ecology not only provides a fresh perspective on microbial classification that goes beyond its intellectual history, but also contextualizes the present focus on diversity. By covering the period of a century, this paper outlines a revised longue durée historiography that takes its inspiration from artifacts, such as Petri dish and the Winogradsky column, and thereby simple, but influential technologies that often remain invisible. This enables the problem of historical continuity in modern science to be addressed and the accelerationist narratives of its development to be countered. (shrink)

The ArgumentThe text analyzes the related semantics of bacteriology and politics in imperial Germany. The rapid success of bacteriology in the 1880s and 1890s was due not least to the fact that scientific concepts of bacteria as “the smallest but most dangerous enemies of mankind” resonated with contemporary ideas about political enemies. Bacteriological hygiene was expected to provide answers to social and political problems. At the same time metaphors borrowed from bacteriological terminology were incorporated into the political language of the (...) time. While the “high command of our doctors” fought diseases, some contemporaries were identified with members of the evil species of “bacillus communis odii.”Both imperialistic politics and bacteriological science relied on images of inferior and invisible but potent enemies. Both were able to increase their prestige via a mutual interchange of their vocabularies. (shrink)

Fetal alcohol syndrome , the most common avoidable human birth defect, is the extensive irreversible brain damage caused by heavy prenatal alcohol exposure. Following the discovery of FAS in 1973, a multidisciplinary research community began applying discipline-specific methods to investigate the mechanisms underlying FAS and its consequences for the victims’ cognition and social behavior. An academic biomathematician and statistician, since 1984 I have collaborated with one American research group studying this condition.

This inaugural handbook documents the distinctive research field that utilizes history and philosophy in investigation of theoretical, curricular and pedagogical issues in the teaching of science and mathematics. It is contributed to by 130 researchers from 30 countries; it provides a logically structured, fully referenced guide to the ways in which science and mathematics education is, informed by the history and philosophy of these disciplines, as well as by the philosophy of education more generally. The first handbook to cover the (...) field, it lays down a much-needed marker of progress to date and provides a platform for informed and coherent future analysis and research of the subject. -/- The publication comes at a time of heightened worldwide concern over the standard of science and mathematics education, attended by fierce debate over how best to reform curricula and enliven student engagement in the subjects There is a growing recognition among educators and policy makers that the learning of science must dovetail with learning about science; this handbook is uniquely positioned as a locus for the discussion. -/- The handbook features sections on pedagogical, theoretical, national, and biographical research, setting the literature of each tradition in its historical context. Each chapter engages in an assessment of the strengths and weakness of the research addressed, and suggests potentially fruitful avenues of future research. A key element of the handbook’s broader analytical framework is its identification and examination of unnoticed philosophical assumptions in science and mathematics research. It reminds readers at a crucial juncture that there has been a long and rich tradition of historical and philosophical engagements with science and mathematics teaching, and that lessons can be learnt from these engagements for the resolution of current theoretical, curricular and pedagogical questions that face teachers and administrators. (shrink)

Introduction to the Dossier - Ludwik Fleck’s Theory of Thought Styles and Thought Collectives: Translations and Receptions.

In his theory of thought style and thought collective, Ludwik Fleck states that every act of cognition is associated with the past of a given eld of science and de‐ eply rooted in the cultural context. He also points out that the way of thinking of all exploring individuals is determined by their past and the past of the eld of knowledge, which is the object of cognition. The individuals are not autonomous; they constitute a part of a certain thought (...) collective, and they are greatly dependent on it. The objective of this article is to nd out whether Ludwik Fleck’s theory can be used to explain religious phenomena and describe the structures of religious groups. The rst part of the article presents the arguments against the existence of an objective picture of the religious reality. Moreover, the author tries to prove the thesis, which assumes that every cognition and every religious experience are of a social na‐ ture. The second part is devoted to the analysis of the structure of religious groups understood as thought collectives. The third part of the article concerns the inadequacy of thought styles. The author also attempts to answer the question of whether the adoption of the proposed assumptions allows for one to enter into disputes over religious matters. (shrink)

Population ageing and increased digitalization each constitute an ongoing and profound transformation within contemporary modes of living, as growing advances in technological development mix and intermingle with the lived realities of older people as the final recipients. It is against the backdrop of this interplay that user involvement has enjoyed ever-rising advocacy to an almost normative degree. Beyond articulating methodological principles, however, the literature has remained surprisingly vague as to the practical implementation of the approach. Less appears to be known, (...) both empirically and conceptually, about how design and user involvement are done in practice and how they would matter to bring about intentional or unintentional effects. To engage with these developments, this thesis aims at taking the practices of user involvement and design to the centre of its inquiry by adopting a perspective from Science and Technology Studies. Specifically, the thesis seeks to both build on and contribute to the established body of STS on the connection between technology design and older users and ask: What is there to learn about user involvement as a method, if we focus on the practices of doing user involvement? To answer this question, the thesis studies four different aspects of the practices of user involvement and design. In particular, the thesis reviews the literature on how user involvement mattered in previous empirical projects that include older people, it examines how different configurations of participation matter in design workshops, it scrutinizes the achievement of user involvement in corporate practices and it traces the circumstantial performances of such practices. The largest empirical piece comes from a two-year ethnographic study of a small- to medium-sized enterprise, the material from which informed Paper III and Paper IV. The findings highlight how user involvement in practice is both contingent and transformative, as it selectively enrols different participants and performs multiple realities. In practice, user involvement appears to be dependent on a set of underlying premises and socio-material conditions and thus is always a dynamic and momentary achievement. Furthermore, the thesis shows how the practices of user involvement themselves may bring into existence different realities, articulating and materializing particular versions of objects and images of ageing. Accordingly, the thesis contributes theoretically by illuminating the underlying socio-material facets of user involvement, and by emphasizing ageing as a particular object/image of design. Specifically, the appended papers encompass a conceptual framework, as well as three new concepts: design multiple, shifting interstices and viscous image landscape, in order to theorize the underlying conditions for user involvement, its relationship with design and its entanglement with ageing. Practically, the thesis enunciates three main implications regarding questions of goodness, politics and ethics. (shrink)

Slightly modified excerpt from the section 13.4 Zusammenfassung und Ausblick (translated into englisch): This chapter is based on an analysis of ethical debates on epigenetics and genome editing, debates, in which ethical arguments relating to future generations and justice play a central role. The analysis aims to contextualize new developments in genetic engineering, such as genome and epigenome editing, ethically. At the beginning, the assumptions of "genetic determinism," on which "genetic essentialism" is based, of "epigenetic determinism" as well as "genetic" (...) and "epigenetic exceptionalism" are analyzed and critically discussed. The remarks on the ethical discourse on epigenetics show that the notion of "epigenetic determinism" can sometimes be discerned not only in popular scientific discourse but also in ethical discourse. Ethical debates on epigenetics, however, have distanced themselves from this deterministic understanding. As a result, the focus in the ethical discourse on epigenetics shifts from responsibility for one's own health and that of subsequent generations to justice. What is meant here is justice, for example, in terms of access to healthy environmental conditions, regardless of whether these contribute to health with or without epigenetic agency. An analysis of the discourse on genome editing reveals that it is primarily germline interventions that are being ethically examined, with a concentration on the aspect of inheritance. The question is whether this is accompanied by an implicit "genetic determinism" or even a "genetic essentialism": the determinism could lie in the centrality of the aspect of heritability, since only genetic information is inherited. Does the aspect of heritability and genome modification play a more decisive role in debates on genome editing than the safety issue? Is the problem of embryos and their potential offspring not being able to consent to germline intervention given such a high priority because it is a genetic intervention? Under such a premise of "strong genetic determinism" supplemented by "epigenetic determinism," not only genome editing but also epigenome editing would be ethically relevant precisely because it too would have an influence on the genome. How this influence of genome editing and epigenome editing is ethically evaluated in each case therefore depends initially on whether the assumptions of "genetic" and "epigenetic determinism" are advocated. These assumptions are increasingly viewed critically in ethical discourse because they cannot be confirmed from a scientific perspective. In popular scientific debates in particular, however, they seem to persist, which ultimately also influences the public discussion. Since a broad public discussion is required especially on genome editing, a reflective approach to the various "-isms" analyzed in this chapter is central. DOI: 10.5771/9783748927242. (shrink)

Historians of science have treated the history of primary, secondary, tertiary, and popular science education, although overall the collective scholarship on these issues remains sparse in comparison to other topics in the history of science. Guided at first by the conceptual frameworks of Thomas Kuhn and Michel Foucault, this literature has moved beyond them to embrace a broader methodological pluralism. This essay examines areas where the scholarship on the history of science education is most developed: the history of tertiary science (...) education and of pedagogical practices in professional settings. Here historians of science have focused mainly on scientific textbooks; science pedagogy, or how science is taught and learned; pedagogical practices in generational reproduction; and finally the political, social, and economic dimensions of science education. The essay concludes by considering how an emerging area of general historical scholarship, the history of the senses, offers an opportunity to add a new dimension to the history of science education. (shrink)

One of the factors that adversely influenced the worldwide reception of Fleck was the rather narrow critical interest that his ideas had aroused in Poland. Apart from a few reviews of his book, only two polemics were published before WWII, and these likewise fell into oblivion. The philosophical views of one of those polemists, Tadeusz Bilikiewicz, shared the same fate. Since an acquaintance with Bilikiewicz’s background would seem to be a necessary condition for a understanding of his controversy with Fleck, (...) the aim of this paper is to sketch his views on the history and sociology of science, and to clarify certain errors regarding the facts of his life. (shrink)

Recent work on Austrian philosophy has revealed, hitherto, unsuspected links between Vienna circle positivism on the one hand, and the thought of Franz Brentano and his circle on the other. the paper explores these links, casting light also on the Polish analytic movement, on the development of gestalt psychology, and on the work of Schlick and Neurath.

In diesem Text möchte ich den Versuch machen, exemplarisch die große Wirkung einzufangen, die Moritz Schlick über den engen Kreis seiner Fachkollegen hinaus auf die akademische Öffentlichkeit Wiens hatte, und sie mit des von Ludwik Fleck geprägten Begriffs des Denkstils genauer zu beschreiben. War Schlick Werbetexter eines Zeitgeistes? Ein wertvolles Dokument für eine Antwort auf diese Frage sind die Erinnerungen an Moritz Schlick und den Wiener Kreis im 2. Kapitel des autobiographischen Essays "Unmeisterliche Wanderjahre" von Jean Améry. Die Rolle, die (...) Schlick darin spielt, wird hier zum ersten Mal eingehend untersucht. Dies fördert eine überraschende politische Dimension seines Wirkens zu Tage. (shrink)

Taking as starting point Kuhn’s analysis of science textbooks and its application to Sinnott and Dunn’s (1925), it will be discussed the problem of the existence of laws in biology. In particular, it will be showed, in accordance with the proposals of Darden (1991) and Schaffner (1980, 1986, 1993), the relevance of the exemplars, diagrammatically or graphically represented, in the way in which is carried out the teaching and learning process of classical genetics, inasmuch as the information contained in them, (...) indispensable for the right development of that process, exceeds the information contained in the “laws” linguistically articulated and presented in the textbooks. However, it will be maintained that the information is implicit in the law that according to the structuralist concept of fundamental law and the reconstruction of genetics presented by Balzer & Dawe (1990), and later developed by Balzer & Lorenzano (1997) and Lorenzano (1995, 2000, 2002a) could be considered the fundamental law of classical genetics,the law of matching, clearly identified in this paper. (shrink)