This paper aims at tracking down, by looking at late medieval and early modern discussions over the ontological status of artifacts, the main steps of the process through which nature became theorized on a mechanistic model in the early 17th century. The adopted methodology consists in examining how inventions such as mechanical clocks and automata forced philosophers to modify traditional criteria based on an intrinsic principle of motion and rest for defining natural beings. The paper studies different strategies designed in (...) the transitional period 1300–1600 for making these inventions compatible with classical definitions of nature and artifacts. In the first part of the paper, it is shown that, even if virtually all medieval philosophers acknowledged an ontological distinction between artifacts and natural beings, these different strategies demonstrate a growing concern about the consistency of the art/nature distinction. The next part of the paper studies how mechanical clocks, even before the Scientific Revolution, served as theoretical models for applying mechanistic views to different objects (be they cosmological, physical or biological). The epistemological function of clocks appears to stem from different factors (like the specific manufacturing of late medieval clocks as well as the evolution of 16th-century mechanics) that are listed in this second part of the paper. These factors, combined with the definitional issues raised by automata, explain that clocks became the symbol of a new approach to natural philosophy, characterized by the collapse of the art/nature distinction and the “mechanization of nature”. (shrink)