In this thesis I investigate causal inquiry in the social sciences, drawing on examples from various disciplines and in particular from conflict studies. In a backlash against the pervasiveness of statistical methods, in the last decade certain social scientists have focused on finding the causal mechanisms behind observed correlations. To provide evidence for such mechanisms, researchers increasingly rely on ‘process tracing’, a method which attempts to give evidence for causal relations by specifying the chain of events connecting a putative cause (...) and effect of interest. I will ask whether the causal claims process tracers make are defensible, and where they are not defensible I will ask how we can improve the method. Throughout these investigations, I show that the conclusions of process tracing are constrained both by the causal structure ofthe social world and by social scientists’ aims and values. My central argument is this: all instances of social phenomena have causally relevant differences, which implies that any research design that requires some comparison between cases is limited by how we systematize these phenomena. Moreover, such research cannot rely on stable regularities. Nevertheless, to forego causal conclusions altogether is not the right response to these limitations; by carefully outlining our epistemic assumptions we can make progress in causal inquiry. While I use philosophical theories of causation to comment on the feasibility of a social scientific method, I also do the reverse: by investigating a popular contemporary method in the social sciences, I show to what extent our philosophical theories of causation are workable in practice. Thus, this thesis is both a methodological and a philosophical work. Every chapter discusses both a fundamental philosophical position on the social sciences and a relevant case study from the social sciences. (shrink)

This paper explores multiple experimental interventions in molecular biology. By “multiple,” we mean that molecular biologists often use different modes of experimental interventions in a series of experiments for one and the same subject. In performing such a series of experiment, scientists may use different modes of interventions to realize plural goals such as testing given hypotheses and exploring novel phenomena. In order to illustrate this claim, we develop a framework of multiple modes of experimental interventions to analyze a series (...) of experiments for a single subject. Our argument begins with a brief characterization of Craver and Darden’s taxonomy of experiments, because the taxonomy they have made implies various modes of interventions. We propose to extract two interventional directions and two interventional effects from their taxonomy as the basis of classification. The vertical or inter-level direction means that an intervention is performed between different levels of organization and the horizontal or inter-stage direction means that an intervention is performed between different stages of a mechanism. Interventions may produce an excitatory or an inhibitory effect. As a consequence, we can classify modes of interventions according to different directions and effects. We illustrate our claims by doing a case study of the PaJaMo experiment, which is a series of experiments for a single subject. The final goal in this paper is to provide a taxonomy of characteristics of experimentation in which the PaJaMo experiment is adequately located. (shrink)

Alexander Gebharter has recently proposed to use Bayesian network causal discovery methods to identify the constitutive dependencies that underwrite mechanistic explanations. The proposal depends on using the assumptions of the causal Bayesian network framework to implicitly define mechanistic constitution as a kind of deterministic direct causal dependence. The aim of this paper is twofold. In the first half, we argue that Gebharter’s proposal incurs severe conceptual problems. In the second half, we present an alternative way to bring Bayesian network tools (...) to bear on the issue of understanding mechanistic constitution. More precisely, our proposal interprets constitution as the relation explaining why a target phenomenon has its characteristic causal role in terms of the causal roles of some of its spatiotemporal parts---where the notion of causal role is probabilistically understood. (shrink)

trying to explain these reactions in terms of changes in ele- began trying to characterize physiological processes in.

Philosophers of science have by and large neglected technology. In this book, I have tried to do something about this lacuna by analyzing a few aspects of technical artifacts from a philosophical angle. The project was part of the research program "The Dual Nature of Technical Artifacts" based at Delft University of Technology in the Netherlands. Technical artifacts are both plain physical objects and objects that have been purposefully made for a purpose; which is to say they have a physical (...) structure and a technical function. As a result, they belong equally in a purely physical conceptualisation of the world "in which human intentions and goals seem to have no place" and in an intentional conceptualisation, which is used to describe and understand people and their mental lives. My main goal was to find out how these two philosophically very different aspects of artifacts are related to one another. To achieve this goal, I looked at two contexts in which these aspects are regularly brought together in a systematic fashion. First, the context of design; design can be characterized as a transition from a desired function or goal to a physical structure. In particular, I have studied and analyzed the role of functional decomposition in design processes. The second context is the explanation of how artifacts are able to fulfill their technical function in virtue of their specific physical structure. The result of this part of the project is a general account of such explanations. (shrink)

The concept of technical function is a key concept to describe technical artifacts and artifacts-to-be-designed. Engineers often give such descriptions in terms of functional decomposition models, which represent relationships between functions and sets of other functions. Despite the importance of the concept of function there is no consensus among engineers about its meaning. Models of functional decomposition are likewise conceptually divergent. Although this conceptual diversity hampers information exchange between engineers, they accept and maintain it. Engineers do not, by and large, (...) engage in a focused debate to establish commonly shared functional conceptualizations. This contrasts with science where both debates on the adequacy of key conceptualizations and convergence toward shared conceptualizations are common. This book investigates the side-by-side usage of different functional decomposition models in engineering. It explains this phenomenon by applying and extending the analysis of theory choice in terms of methodological incommensurability to engineering functional decomposition, rather than to science. This analysis shows that engineers’ usage of competing functional decomposition models is rational from a practical point of view. This book furthermore investigates the communication problems that the side-by-side usage of different models engenders and presents a strategy that supports the exchange and re-use of functional information between engineers. (shrink)

What is the relationship between pain and the body? I claim that pain is best explained as a type of personal experience and the bodily response during pain is best explained in terms of a type of mechanical neurophysiologic operation. I apply the radical philosophy of identity theory from philosophy of mind to the relationship between the personal experience of pain and specific neurophysiologic mechanism and argue that the relationship between them is best explained as one of type identity. Specifically, (...) pain is a specific type of personal experience identical to a specific type of allostatic stress response comprised of interdependent nervous, endocrine and immune mechanical operations. (shrink)

Leuridan (2011) questions whether mechanisms can really replace laws at the heart of our thinking about science. In doing so, he enters a long-standing discussion about the relationship between the mech-anistic structures evident in the theories of contemporary biology and the laws of nature privileged especially in traditional empiricist traditions of the philosophy of science (see e.g. Wimsatt 1974; Bechtel and Abrahamsen 2005; Bogen 2005; Darden 2006; Glennan 1996; MDC 2000; Schaffner 1993; Tabery 2003; Weber 2005). In our view, Leuridan (...) misconstrues this discussion. His weak positive claim that mechanistic sciences appeal to generalizations is true but uninteresting. His stronger claim, that all causal claims require laws, is unsupported by his arguments. Though we proceed by criticizing Leuridan’s arguments, our greater purpose is to embellish his arguments in order to show how thinking about mechanisms enriches and transforms old philosophical debates about laws in biology and provides new insights into how generalizations afford prediction, explanation and control. (shrink)

The goal of this article is to show that formal analysis and reconstructions may be useful to discuss and shed light on substantive meta-theoretical issues. We proceed here by exemplification, analysing and reconstructing as a case study a paradigmatic biochemical theory, the Monod-Wyman-Changeux theory of allosterism, and applying the reconstruction to the discussion of some issues raised by prominent representatives of the new mechanist philosophy. We conclude that our study shows that at least in this case mechanicism and more traditional (...) accounts are not rivals but complementary approaches. (shrink)

Resumen: La capacidad unificadora de una teoría científica es un rasgo usualmente contemplado a la hora de evaluar su adecuación. Kitcher ha elucidado satisfactoriamente tal noción mediante su enfoque de los patrones explicativos. Sin embargo, su perspectiva adolece de ciertas carencias. Concretamente, sostendremos que el requisito de rigurosidad de los patrones para evaluar la capacidad unificadora debe ser repensado, pues atenta contra la heterogeneidad característica de las diferentes aplicaciones de teorías unificadoras. A su vez, mostraremos cómo estas dificultades bien pueden (...) ser subsanadas desde el marco del estructuralismo metateórico sin por ello resignar ninguna de las acertadas intuiciones de Kitcher. -/- Palabras clave: Explicación, Kitcher, estructuralismo metateórico, unificación, unificación espuria. -/- Abstract: Kitcher has satisfactorily explicated unification using his particular approach to scientific explanation. However, we believe that his perspective has certain problems, which have been inherited by more recent approaches to the topic. Specifically, the requirement of stringency of patterns that Kitcher proposes to determine the unifying power of an explanatory pattern undermines the typical and peculiar heterogeneity we can find in different applications of unifying theories. We will show how this topic can be better addressed by the perspective built by metatheoretical structuralism without sacrificing any of Kitcher’s correct intuitions. -/- Keywords: Explanation, Kitcher, metatheoretical structuralism, spurious unification, unification. (shrink)

Barnes, A. and P. Thagard Empathy and analogy. Dialogue: Canadian Philosophical Review, 36: 705-720. HTML Croft, D., & Thagard, P.. Dynamic imagery: A computational model of motion and visual analogy. In L. Magnani and N. Nersessian, Model-based reasoning: Science, technology, values. New York: Kluwer/Plenum, 259-274. PDF only. HTML description of program and code for DIVA.

Las corrientes manipulabilistas tradicionales consideran que una implementación de política efectiva debe estar fundamentada en un conocimiento invariante. Este modo de pensamiento está basado en el supuesto ontológico de que existen factores causales estables tanto en las ciencias naturales como en las sociales. También asumen que un sólo tipo de intervención ex-ante es pertinente para una implementación efectiva. En el presente artículo se realizará una crítica a estos enfoques. En particular, se mostrará que los procesos sociales responden a una lógica (...) de “árboles de posibilidades” o “resultados de final abierto”. Sobre la base de esta variante ontológica se argumentará que más que un conocimiento de factores invariantes, el sustento de una buena política debe buscarse en los condicionamientos explicitados dentro de un anteproyecto y en la factibilidad de que los mismos se satisfagan en el sistema objetivo. Asimismo, se mostrará cómo las típicas intervenciones ex-ante no son adecuadas en el reino de lo social. Contrario a ellos, las intervenciones deberán ser sistemáticas. (shrink)

The notion of emergence has accompanied philosophy of science since the late XIX century, claiming that in some systems there are properties in certain levels that cannot be deduced from properties of their components as seen in more fundamental levels. Throughout the XX century, emergence has been characterized by four pillars: unpredictability, novelty, restriction and downward causation. These four pillars have been related to the assumption of a hierarchical order of reality in different levels of organization. In this paper, we (...) show that it is possible to explain the nature of the emergent properties through the nearly-decomposability criterion introduced by Herbert Simon. (shrink)

While some philosophers of history have argued that explanations in human history are of a fundamentally different kind than explanations in the natural sciences, I shall argue that this is not the case. Human beings are part of nature, human history is part of natural history, and human historical explanation is a species of natural historical explanation. In this paper I shall use a case study from the history of the American Civil War to show the variety of close parallels (...) between natural and human historical explanation. In both instances, I shall argue that these explanations involve narrative descriptions of causal mechanisms. I shall show how adopting a mechanistic approach to explanation can provide resources to address some important aspects of human historiographic explanation, including problems concerning event individuation, historical meaning, agency, the role of laws, and the nature of contingency. (shrink)

During the 1990s, many philosophers wrestled with the problem of function indeterminacy. Although interest in the problem has waned, I argue that solving the problem is of value for biomedical research and practice. This is because a solution to the problem is required in order to specify rigorously the conditions under which a given item is “dysfunctional.” In the following I revisit a solution developed originally by Neander, which uses functional analysis to solve the problem. I situate her solution in (...) the framework of mechanistic explanation and suggest two improvements. (shrink)

In the recent philosophical literature, two questions have arisen concerning the status of natural selection: (1) Is it a population-level phenomenon, or is it an organism-level phenomenon? (2) Is it a causal process, or is it a purely statistical summary of lower-level processes? In an earlier work (Millstein, Br J Philos Sci, 57(4):627–653, 2006), I argue that natural selection should be understood as a population-level causal process, rather than a purely statistical population-level summation of lower-level processes or as an organism-level (...) causal process. In a 2009 essay entitled “Productivity, relevance, and natural selection,” Stuart Glennan argues in reply that natural selection is produced by causal pro- cesses operating at the level of individual organisms, but he maintains that there is no causal productivity at the population level. However, there are, he claims, many population-level properties that are causally relevant to the dynamics of evolution- ary processes. Glennan’s claims rely on a causal pluralism that holds that there are two types of causes: causal production and causal relevance. Without calling into question Glennan’s causal pluralism or his claims concerning the causal relevance of natural selection, I argue that natural selection does in fact exhibit causal production at the population level. It is true that natural selection does not fit with accounts of mechanisms that involve decomposition of wholes into parts, such as Glennan’s own. However, it does fit with causal production accounts that do not require decomposition, such as Salmon’s Mark Transmission account, given the extent to which populations act as interacting “objects” in the process of natural selection. (shrink)

Mechanism is undoubtedly a causal concept, in the sense that ordinary definitions and philosophical analyses explicate the concept in terms of other causal concepts such as production and interaction. Given this fact, many philosophers have supposed that analyses of the concept of mechanism, while they might appeal to philosophical theories about the nature of causation, could do little to inform such theories. On the other hand, methods of causal inference and explanation appeal to mechanisms. Discovering a mechanism is the gold (...) standard for establishing and explaining causal connections. This fact suggests that it might be possible to provide an analysis of causation that appeals to mechanisms. (shrink)

Most philosophical debate over mental causation has been concerned with reconciling commonsense intuitions that there are causal interactions between the mental and the physical with philosophical theories of the nature of the mental that seem to suggest otherwise. My concern is with a different and more practical problem. We often confront some cognitive, affective, or bodily phenomenon, and wonder about its source – its etiology or its underlying causal basis. For instance, you might wonder whether your queasiness due to something (...) you ate, or whether it is just nervousness, or whether your aunt’s memory loss is a neurological problem or a psychological response to trauma. Such questions attempt to localize the causes of a phenomenon at some level in the complex multi-level systems that we human animals are. In this paper I will attempt to tease out the sense of level implicit in such questions, and to show how it is related to current mechanistic accounts of levels. I will argue that the explanation of our practices of level attribution is deeply pragmatic. Such attributions are often attempts to locate the causes of problems, and to identify interventions that could solve those problems. (shrink)

A number of areas of biology raise questions about what is of value in the natural environment and how we ought to behave towards it: conservation biology, environmental science, and ecology, to name a few. Based on my experience teaching students from these and similar majors, I argue that the field of environmental ethics has much to teach these students. They come to me with pent-up questions and a feeling that more is needed to fully engage in their subjects, and (...) I believe some exposure to environmental ethics can help focus their interests and goals. I identify three primary areas in which environmental ethics can con- tribute to their education. The first is an examination of who (or what) should be considered to be part of our moral community (i.e., the community to whom we owe direct duties). Is it humans only? Or does it include all sentient life? Or all life? Or ecosystems considered holistically? Often, readings implicitly assume one or more of these answers; the goal is to make the student more sensitive to these implicit claims and to get them to think about the different reasons that support them. The second area, related to the first, is the application of the different answers concerning the extent of the ethical community to real environmental issues and problems. Students need to be aware of how the different answers concerning the moral community can imply conflicting answers for how we should act in certain cases and to think about ways to move toward conflict resolution. The third area in which environmental ethics can contribute is a more conceptual one, focusing on central concepts such as biodiversity, sustainability, species, and ecosystems. Exploring and evaluating various meanings of these terms will make students more reflective and thoughtful citizens and biologists, sensitive to the implications that different conceptual choices make. (shrink)

In this paper, we critically analyze the mechanicist approach to scientific explanation and propose to complement this view with a conception of level as interval of quasi-decompositionality. This conception allows us to metaphysically base the mechanicist proposals on characteristic systemic features. By means of concrete examples, we claim that this proposal is able to overcome some of the alleged limitations of predominant models of mechanistic explanation.

Craver’s (2007) account of explanation in neurobiology offers one of the most sophisticated explications of the mechanism concept. This paper argues that despite groundbreaking advances in understanding mechanistic explanation, serious challenges remain. The first goal of this paper is to address the notorious problem of explanatory relevance concerning mechanistic explanation. I argue that Craver underestimates the importance of pragmatic constraints on the individuation of mechanisms, and that his suggestion for a solution of the explanatory relevance problem is therefore insufficient on (...) several counts. My second goal is to develop an alternative that explicitly incorporates both pragmatic and ontic aspects of mechanism individuation. (shrink)

In this thesis, I give a metascientific account of causality in medicine. I begin with two historical cases of causal discovery. These are the discovery of the causation of Burkitt’s lymphoma by the Epstein-Barr virus, and of the various viral causes suggested for cervical cancer. These historical cases then support a philosophical discussion of causality in medicine. This begins with an introduction to the Russo- Williamson thesis (RWT), and discussion of a range of counter-arguments against it. Despite these, I argue (...) that the RWT is historically workable, given a small number of modifications. I then expand Russo and Williamson’s account. I first develop their suggestion that causal relationships in medicine require some kind of evidence of mechanism. I begin with a number of accounts of mechanisms and produce a range of consensus features of them. I then develop this consensus position by reference to the two historical case studies with an eye to their operational competence. In particular, I suggest that it is mechanistic models and their representations which we are concerned with in medicine, rather than the mechanism as it exists in the world. -/- I then employ these mechanistic models to give an account of the sorts of evidence used in formulating and evaluating causal claims. Again, I use the two human viral oncogenesis cases to give this account. I characterise and distinguish evidence of mechanism from evidence of difference-making, and relate this to mechanistic models. I then suggest the relationship between types of evidence presents us with a means of tackling the reference-class problem. This sets the scene for the final chapter. Here, I suggest the manner in which these two different classes of evidence become integrated is also reflected in the way that developing research programmes change as their associated causal claims develop. (shrink)

Recent discussion of mechanism has suggested new approaches to several issues in the philosophy of science, including theory structure, causal explanation, and reductionism. Here, I apply what I take to be the fruits of the 'new mechanical philosophy' to an analysis of a contemporary debate in evolutionary biology about the role of natural selection in speciation. Traditional accounts of that debate focus on the geographic context of genetic divergence--namely, whether divergence in the absence of geographic isolation is possible (or significant). (...) Those accounts are at best incomplete, I argue, because they ignore the mechanisms producing divergence and miss what is at stake in the biological debate. I argue that the biological debate instead concerns the scope of particular speciation mechanisms which assign different roles to natural selection at various stages of divergence. The upshot is a new interpretation of the crux of that debate--namely, whether divergence with gene flow is possible (or significant) and whether the isolating mechanisms producing it are adaptive. (shrink)

One of the central aims of science is explanation: scientists seek to uncover why things happen the way they do. This chapter addresses what kinds of explanations are formulated in biology, how explanatory aims influence other features of the field of biology, and the implications of all of this for biology education. Philosophical treatments of scientific explanation have been both complicated and enriched by attention to explanatory strategies in biology. Most basically, whereas traditional philosophy of science based explanation on derivation (...) from scientific laws, there are many biological explanations in which laws play little or no role. Instead, the field of biology is a natural place to turn for support for the idea that causal information is explanatory. Biology has also been used to motivate mechanistic accounts of explanation, as well as criticisms of that approach. Ultimately, the most pressing issue about explanation in biology may be how to account for the wide range of explanatory styles encountered in the field. This issue is crucial, for the aims of biological explanation influence a variety of other features of the field of biology. Explanatory aims account for the continued neglect of some central causal factors, a neglect that would otherwise be mysterious. This is linked to the persistent use of models like evolutionary game theory and population genetic models, models that are simplified to the point of unreality. These explanatory aims also offer a way to interpret many biologists’ total commitment to one or another methodological approach, and the intense disagreements that result. In my view, such debates are better understood as arising not from different theoretical commitments, but commitments to different explanatory projects. Biology education would thus be enriched by attending to approaches to biological explanation, as well as the unexpected ways that these explanatory aims influence other features of biology. I suggest five lessons for teaching about explanation in biology that follow from the considerations of this chapter. (shrink)

I argue for a manipulationist-mechanistic framework for content-NCC research in the case of visual consciousness (Bechtel 2008; Neisser 2012). Reference to mechanisms is common in the NCC research. Furthermore, recent developments in non-invasive brain stimulation techniques (NIBS) lend support to a manipulationist standpoint. The crucial question is to understand what is changed after manipulation of a brain mechanism. In the second part of the paper I review the literature on intentionalism, and argue that intervention on the neural mechanism is likely (...) to change the intentional content of consciousness. This urges us to shift from content-NCC to what I call “intentional mechanisms”. Such mechanisms, it is argued, should be understood as neural prerequisites of conscious visual experience. (shrink)

As much as assumptions about mechanisms and mechanistic explanation have deeply affected psychology, they have received disproportionately little analysis in philosophy. After a historical survey of the influences of mechanistic approaches to explanation of psychological phenomena, we specify the nature of mechanisms and mechanistic explanation. Contrary to some treatments of mechanistic explanation, we maintain that explanation is an epistemic activity that involves representing and reasoning about mechanisms. We discuss the manner in which mechanistic approaches serve to bridge levels rather than (...) reduce them, as well as the different ways in which mechanisms are discovered. Finally, we offer a more detailed example of an important psychological phenomenon for which mechanistic explanation has provided the main source of scientific understanding. (shrink)

It is no secret that scientists argue. They argue about theories. But even more, they argue about the evidence for theories. Is the evidence itself trustworthy? This is a bit surprising from the perspective of traditional empiricist accounts of scientific methodology according to which the evidence for scientific theories stems from observation, especially observation with the naked eye. These accounts portray the testing of scientific theories as a matter of comparing the predictions of the theory with the data generated by (...) these observations, which are taken to provide an objective link to reality. (shrink)

Modeling mechanisms is central to the biological sciences – for purposes of explanation, prediction, extrapolation, and manipulation. A closer look at the philosophical literature reveals that mechanisms are predominantly modeled in a purely qualitative way. That is, mechanistic models are conceived of as representing how certain entities and activities are spatially and temporally organized so that they bring about the behavior of the mechanism in question. Although this adequately characterizes how mechanisms are represented in biology textbooks, contemporary biological research practice (...) shows the need for quantitative, probabilistic models of mechanisms, too. In this paper we argue that the formal framework of causal graph theory is well-suited to provide us with models of biological mechanisms that incorporate quantitative and probabilistic information. On the ba-sis of an example from contemporary biological practice, namely feedback regulation of fatty acid biosynthesis in Brassica napus, we show that causal graph theoretical models can account for feedback as well as for the multi-level character of mechanisms. However, we do not claim that causal graph theoretical representations of mechanisms are advantageous in all respects and should replace common qualitative models. Rather, we endorse the more balanced view that causal graph theoretical models of mechanisms are useful for some purposes, while being insufficient for others. (shrink)

In the philosophical tradition, the notions of determinism and causality are strongly linked: it is assumed that in a world of deterministic laws, causality may be said to reign supreme; and in any world where the causality is strong enough, determinism must hold. I will show that these alleged linkages are based on mistakes, and in fact get things almost completely wrong. In a deterministic world that is anything like ours, there is no room for genuine causation. Though there may (...) be stable enough macro-level regularities to serve the purposes of human agents, the sense of “causality” that can be maintained is one that will at best satisfy Humeans and pragmatists, not causal fundamentalists. (shrink)