During the past two decades, philosophers of biology have increasingly turned their attention to mechanisms of biological phenomena. Through analyses of mechanistic proposals advanced by biologists, the goal of these philosophers is to understand what a mechanism is and how mechanisms explain. These analyses have generally focused on mechanistic proposals for phenomenon that occur at the cellular or sub-cellular level, such as synapse firing, protein synthesis, or metabolic pathway operation. Little is said about the mechanisms of the macromolecular reactions that (...) underpin these phenomena. These reactions comprise a diverse family of reaction types, and include protein folding, macromolecular complex formation, receptor-ligand interactions, and enzyme catalysis. In this paper, I develop an account of mechanism that focuses exclusively on macromolecular reactions. I begin by reviewing how mechanism is understood in enzymology, and how mechanistic concepts of enzymology apply to macromolecular reactions in general. We will see that the mechanism of a macromolecular reaction is most accurately described as a progression of reaction intermediates, where the evolution of intermediates, from one to the next, is characterized by an energetic coupling between chemistry and protein dynamics. I then make the case that this description necessitates a grounding in a process ontology. To describe the mechanism by which a macromolecular reaction occurs is to describe a process. (shrink)

In this article I concentrate on three issues. First, Graham Oppy’s treatment of the relationship between the concept of infinity and Zeno’s paradoxes lay bare several porblems that must be dealt with if the concept of infinity is to do any intellectual work in philosophy of religion. Here I will expand on some insightful remarks by Oppy in an effort ot adequately respond to these problems. Second, I will do the same regarding Oppy’s treatment of Kant’s first antinomy in the (...) first critique, which deals in part with the question of whether the world had a beginning in time or if time extends infinitely into the past. And third, my examination of these two issues will inform what I have to say regarding a key topic in philosophy of religion: the question regarding the proper relationship between the infinite and the finite in the concept of God. (shrink)

Pragmatism has played only a small role in the half century and more of the science‐and‐religion dialogue, in part because pragmatism was at a low ebb in the 1950s. Even though Jamesean pragmatism in particular is experiencing a resurgence, owing partly to the work of Rorty and Putnam, it remains inconspicuous in the dialogue. Excepting artificial intelligence and artificial life, computer science also has not played a large role in the dialogue. Recent research into the foundations of object‐oriented programming, however, (...) shows this increasingly pervasive practice possesses an implicit pragmatist epistemology. Although science will have to become more computational, it will have to come to terms with both object‐oriented computing and its implicit pragmatism, which in turn supports the conclusion that we have fresh warrant for recasting the science‐and‐religion dialogue in Jamesean pragmatist terms. Some preliminary consequences of such a recasting of the dialogue are explored. (shrink)

On the assumption that theistic religious commitment takes place in the face of evidential ambiguity, the question arises under what conditions it is permissible to make a doxastic venture beyond one’s evidence in favour of a religious proposition. In this paper I explore the implications for orthodox theistic commitment of adopting, in answer to that question, a modest, moral coherentist, fideism. This extended Jamesian fideism crucially requires positive ethical evaluation of both the motivation and content of religious doxastic ventures. I (...) suggest that, even though the existence of horrendous evil does not resolve evidential ambiguity in favour of atheism, there are reasonable value commitments that would preclude those who hold them from satisfying extended Jamesian fideist conditions for committing themselves to classical theism. I then begin a discussion of a possible revisionary theistic alternative (in the Christian tradition) which – one might hope – may meet those conditions. An earlier, shorter, version of this paper was delivered as a keynote address at the APA Pacific 2007 Mini-Conference on Models of God. (shrink)