This dissertation explores various attempts to solve the Dependence Problem problem posed by the following question: How can necessary truths stand to God in a one-way relation of dependence, given that neither they nor God could have failed to exist?

This essay defends two theses that jointly establish a link between causal and explanatory asymmetry. The first thesis is that statements specifying facts about effects, unlike statements specifying facts about causes, are not "independently variable". The second thesis is that independent variability among purportedly explanatory factors is a necessary condition on scientific explanations.