In this paper I claim that the goal of mapping and sequencing the human genome is not wholly new, but rather is an extension of an older project to map genes, a central aim of genetics since its birth. Thus, the discussion about the value of the HGP should not be posed in global terms of acceptance or rejection, but in terms of how it should be developed. The first section of this paper presents a brief history of the project. (...) The second section distinguishes among four kinds of issues relevant to an evaluation of the HGP: those economic and organizational issues related to the feasibility of the project; the ethical questions arising in the development of the project and the application of the data gathered; the empirical issues relevant to the scientific value of the project; and conceptual issues like reductionism and determinism relevant to understand the nature and scope of the project. In a third section, I analyze in detail whether the HGP and, more generally, molecular biology is reductionistic. (shrink)

In the late 1720s, Daniel Turner and James Blondel engaged in a pamphlet dispute over the power of the maternal imagination. Turner accepted the long-standing belief that a pregnant woman's imagination could be transferred to her unborn child, imprinting the foetus with various marks and deformities. Blondel sought to refute this view on rational and anatomical grounds. Two issues repeatedly received these authors' attention: the identity of imagination, and its power in pregnant women; and the process of generation and foetal (...) development. In their discussions of these issues, differences between the authors' acceptance of general medical theories and philosophies became apparent. Blondel invoked Newtonian matter theory, experimental philosophy, and iatro-mechanism, while Turner adhered more to the authority of the Ancients and advocated a more direct role for the Creator as an alternative to mechanism in explaining natural phenomena. Additionally, the authors held differing views of what they regarded as experience. The widespread contemporary interest in their dispute suggests that Turner and Blondel raised the phenomenon of the maternal imagination from an issue of folk belief to a concern of eighteenth-century medicine. (shrink)

Urban sprawl’s negative impacts have been amply demonstrated, starting as long as 30 years ago, and most North American urban plans have, somewhere, reference to sprawl as bad policy. Yet North Americans continue to tolerate the construction of more and more suburban subdivisions. This paper suggests an answer to this paradox. We argue that sprawl’s attractiveness – if one can call it that – is buried deep in North American cultural predispositions, which we trace to quite specific interpretations of the (...) mechanistic worldview that emerged from 17th and 18th century revolutions in natural philosophy. North American culture is a scientific culture as well as a suburban one. If mechanistic science and its peculiar view of nature is so pervasive and if suburban sprawl is both pervasive and dysfunctional, then this particular form of science and its cultural roots need to be carefully examined. We do this from the perspective of the 21st century, when quantum physics and new discoveries in the ecological and biological sciences are suggesting that many commonly accepted assumptions about physical reality inherited from 17th and 18th century science are flawed. (shrink)

The ArgumentThis essay addresses the historiographical question of how to study scientific instruments and the connections between them without rigidly determining the boundaries of the object under historical scrutiny beforehand. To do this, I will explore an episode in the early history of the tachistoscope — defined, among other things, as an instrument for the brief exposure of visual stimuli in experimental psychology. After looking at the tachistoscope described by physiologist Volkmann in 1859, I will turn to the gravity chronometer, (...) constructed by Cattell at Wundt's Leipzig institute of psychology in the 1880s. Taking Wittgenstein's notion of family resemblances as a methodological suggestion to travel from one member to another to find out just how members relate to one another, I will investigate part of the family to which both the tachistoscope and the gravity chronometer turn out to belong. A detailed analysis of these instruments, using both historical sources and historical accounts of psychological instruments, may demonstrate that the instrument is not a standard package that, if well applied, will simply secure good results. Each package needs to be assembled again and again; the particular package that is assembled may differ on different occasions. Thus an alternative is developed to an understanding of instruments as univocally functioning material means. (shrink)

The ArgumentThis paper focuses on several Italian Jewish philosophers in the second half of the sixteenth century and the first third of the seventeenth century. It argues that their writings share a certain theology of nature. Because of it, the interest of Jews in the study of nature was not a proto-scientific but a hermeneutical activity based on the essential correspondence between God, Torah, and Israel. While the theology of nature analyzed in the paper did not prevent Jews from being (...) informed about and selectively endorsing the first phase of the scientific revolution, it did render the Jews marginal to it. So long as Jewish thinkers adhered to this theology of nature, Jews could not adopt the scientific mentality that presupposed a qualitative distinction between the Book of Nature and the Book of Scripture. (shrink)

Those standard historiographic themes of "evolution" and "revolution" need replacing. They perpetuate mid-Victorian scientists' history of science. Historians' history of science does well to take in the long run from the Greek and Hebrew heritages on, and to work at avoiding misleading anachronism and teleology. As an alternative to the usual "evo-revo" themes, a historiography of origins and species, of cosmologies and ontologies, is developed here. The advantages of such a historiography are illustrated by looking briefly at a number of (...) transitions: the transition from Greek and Hebrew doctrines to their integrations by medieval authors; the transition from the Platonist, Aristotelian, Christian Aquinas to the Newtonian Buffon and to the no less Newtonian Lamarck; the departures the early Darwin made away from Lamarck's and from Lyell's views. Issues concerning historical thinking about nature, concerning essentialism and concerning classification are addressed in an attempt to challenge customary stereotypes. Questions about originality and influence are raised, especially concerning Darwin's "tree of life" scheme. The broader historiography of Darwinian science as a social ideology, and as a "worldview," is examined and the scope for revisions emphasised. Throughout, graduate students are encouraged to see this topic area not as worked out, but as full of opportunities for fresh contributions. (shrink)

Summary The addition of ‘fire’ to the European battle repertoire resulted in the close-order drill for manoeuvres of the line. Begun in late sixteenth-century Netherlands and perfected in eighteenth-century Prussia under Frederick the Great, the drill's precision marching evolved into a military science which conceived what infantry acquired through rigorous training as a lawful ‘second nature’ of men. In contrast, the liberal Webers' 1836 locomotion research orientation was, as was that of French skirmishing, one of natural self-regulation. Later Prussian military (...) science, restored in Imperial Germany, was merged into locomotion science. (shrink)

The central terms of certain theories which were valued highly in the past, such as the phlogiston theory, are now believed by realists not to refer. Laudan and others have claimed that, in the light of the existence of such theories, scientific realism is untenable. This paper argues in response that realism is consistent with — and indeed is able to explain — such theories' having been highly valued and yet not being close to the truth. It follows that the (...) set of highly-valued past theories cited by Laudan, presumed to militate against realism, is in fact innocuous to the doctrine. The argument hinges largely on identifying the grounds on which theory-adoption is actually performed. (shrink)

TheCatalogue of Scientific Papers, published by the Royal Society of London beginning in 1867, projected back to the beginning of the nineteenth century a novel vision of the history of science in which knowledge was built up out of discrete papers each connected to an author. Its construction was an act of canon formation that helped naturalize the idea that scientific publishing consisted of special kinds of texts and authors that were set apart from the wider landscape of publishing. By (...) recovering the decisions and struggles through which theCataloguewas assembled, this essay aims to contribute to current efforts to denaturalize the scientific paper as the dominant genre of scientific life. By privileging a specific representation of the course of a scientific life as a list of papers, theCataloguehelped shape underlying assumptions about the most valuable fruits of a scientific career. Its enumerated lists of authors’ periodical publications were quickly put to use as a means of measuring scientific productivity and reputation, as well as by writers of biography and history. Although it was first conceived as a search technology, this essay locates theCatalogue’s most consequential legacy in its uses as a technology of valuation. (shrink)

Science in film, and usual equivalents such asscience on filmorscience on screen, refer to the cinematographic representation, staging, and enactment of actors, information, and processes involved in any aspect or dimension of science and its history. Of course, boundaries are blurry, and films shot as research tools or documentation also display science on screen. Nonetheless, they generally count asscientific film, andscience inandon filmorscreentend to designate productions whose purpose is entertainment and education. Moreover, these two purposes are often combined, and inherently (...) concern empirical, methodological, and conceptual challenges associated withpopularization,science communication, and thepublic understanding of science. It is in these areas that the notion of thedeficit modelemerged to designate a point of view and a mode of understanding, as well as a set of practical and theoretical problems about the relationship between science and the public. (shrink)

The historiographic tradition of the history of science that originated with Auguste Comte bears all the marks of narratives with roots in the Enlightenment, such as a view of religion as an underdeveloped stage in the ascending road in humanity's quest for a more mature understanding. This article explores the development of the peripheral branch of a tradition that developed in Argentina by the mid‐twentieth century with authors such as the Italians Aldo Mieli, José Babini, and the Hungarian Desiderius Papp. (...) It is argued that, contrary to the historiographic program of the conflict thesis developed in English‐speaking countries, those scholars who cultivated the kind of “positivist” history of science that thrived in continental Europe were inclined to see science as a social and epistemological replacement of a fossilized religious outlook. In the final section, I suggest a way to relate the more or less strong versions of the conflict thesis to different patterns of secularization. (shrink)

Preparative and analytical methods developed by separation scientists have played an important role in the history of molecular biology. One such early method is gel electrophoresis, a technique that uses various types of gel as its supporting medium to separate charged molecules based on size and other properties. Historians of science, however, have only recently begun to pay closer attention to this material epistemological dimension of biomolecular science. This paper substantiates the historiographical thread that explores the relationship between modern laboratory (...) practice and the production of scientific knowledge. It traces the historical development of gel electrophoresis from the mid-1940s to the mid-1960s, with careful attention to the interplay between technical developments and disciplinary shifts, especially the rise of molecular biology in this time-frame. Claiming that the early 1950s marked a decisive shift in the evolution of electrophoretic methods from moving boundary to zone electrophoresis, I reconstruct various trajectories in which scientists such as Oliver Smithies sought out the most desirable solid supporting medium for electrophoretic instrumentation. Biomolecular knowledge, I argue, emerged in part from this process of seeking the most appropriate supporting medium that allowed for discrete molecular separation and visualization. The early 1950s, therefore, marked not only an important turning point in the history of separation science, but also a transformative moment in the history of the life sciences as the growth of molecular biology depended in part on the epistemological access to the molecular realm available through these evolving technologies. (shrink)