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  1. Eight Strategies to Engineer Acceptance of Human Germline Modifications.Shoaib Khan & Katherine Drabiak - 2024 - Journal of Bioethical Inquiry 21 (1):81-94.
    Until recently, scientific consensus held firm that genetically manipulated embryos created through methods including Mitochondrial Replacement Therapy or human germline genome editing should not be used to initiate a pregnancy. In countries that have relevant laws pertaining to heritable human germline modifications, the vast majority prohibit or restrict this practice. In the last several years, scholars have observed a transformation of scientific and policy restrictions with insistent calls for creating a regulatory pathway. Multiple stakeholders highlight the role of social consensus (...)
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  • Three Challenges for the Cosmopolitan Governance of Technoscience.Matthew Sample - manuscript
    Promising new solutions or risking unprecedented harms, science and its technological affordances are increasingly portrayed as matters of global concern, requiring in-kind responses. In a wide range of recent discourses and global initiatives, from the International Summits on Human Gene Editing to the Intergovernmental Panel on Climate Change, experts and policymakers routinely invoke cosmopolitan aims. The common rhetoric of a shared human future or of one humanity, however, does not always correspond to practice. Global inequality and a lack of accountability (...)
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  • Researching the future: scenarios to explore the future of human genome editing.Cynthia Selin, Lauren Lambert, Stephanie Morain, John P. Nelson, Dorit Barlevy, Mahmud Farooque, Haley Manley & Christopher T. Scott - 2023 - BMC Medical Ethics 24 (1):1-12.
    Background Forward-looking, democratically oriented governance is needed to ensure that human genome editing serves rather than undercuts public values. Scientific, policy, and ethics communities have recognized this necessity but have demonstrated limited understanding of how to fulfill it. The field of bioethics has long attempted to grapple with the unintended consequences of emerging technologies, but too often such foresight has lacked adequate scientific grounding, overemphasized regulation to the exclusion of examining underlying values, and failed to adequately engage the public. Methods (...)
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  • Constitutionalism at the Nexus of Life and Law.Krishanu Saha, Sheila Jasanoff & J. Benjamin Hurlbut - 2020 - Science, Technology, and Human Values 45 (6):979-1000.
    This essay introduces a collection of articles gathered under the theme of “law, science, and constitutions of life.” Together, they explore how revolutions in notions of what biological life is are eliciting correspondingly revolutionary imaginations of how life should be governed. The central theoretical contribution of the collection is to further elaborate the concept of bioconstitutionalism, which draws attention to especially consequential forms of coproduction at the law–life nexus. This introduction offers a theoretical discussion of bioconstitutionalism. It explores the constitutional (...)
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  • Modular Ontologies for Genetically Modified People and their Bioethical Implications.Derek So, Robert Sladek & Yann Joly - 2024 - NanoEthics 18 (2):1-35.
    Participants in the long-running bioethical debate over human germline genetic modification (HGGM) tend to imagine future people abstractly and on the basis of conventionalized characteristics familiar from science fiction, such as intelligence, disease resistance and height. In order to distinguish these from scientifically meaningful terms like “phenotype” and “trait,” this article proposes the term “persemes” to describe the units of difference for hypothetical people. In the HGGM debate, persemes are frequently conceptualized as similar, modular entities, like building blocks to be (...)
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