The present paper aims at contributing to the ethical debate on the impacts of artificial intelligence (AI) systems on human autonomy. More specifically, it intends to offer a clearer understanding of the design challenges to the effort of aligning driving automation technologies to this ethical value. After introducing the discussion on the ambiguous impacts that AI systems exert on human autonomy, the analysis zooms in on how the problem has been discussed in the literature on connected and automated vehicles (CAVs). (...) On this basis, it is claimed that the issue has been mainly tackled on a fairly general level, and mostly with reference to the controversial issue of crash-optimization algorithms, so that only limited design insights have been drawn. However, integrating ethical analysis and design practices is critical to pursue the implementation of such an important ethical value into CAV technologies. To this aim, it is argued, a more applied approach targeted at examining the impacts on human autonomy of current CAV functions should also be explored. As an example of the intricacy of this task, the case of automated route planning is discussed in some detail. (shrink)