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  1. Should Research Ethics Encourage the Production of Cost-Effective Interventions?Govind Persad - 2016 - In Daniel Strech & Marcel Mertz (eds.), Ethics and Governance of Biomedical Research: Theory and Practice. Cham: Springer. pp. 13-28.
    This project considers whether and how research ethics can contribute to the provision of cost-effective medical interventions. Clinical research ethics represents an underexplored context for the promotion of cost-effectiveness. In particular, although scholars have recently argued that research on less-expensive, less-effective interventions can be ethical, there has been little or no discussion of whether ethical considerations justify curtailing research on more expensive, more effective interventions. Yet considering cost-effectiveness at the research stage can help ensure that scarce resources such as tissue (...)
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  • Cost-Effectiveness and the Avoidance of Discrimination in Healthcare: Can We Have Both?Kasper Lippert-Rasmussen - 2023 - Cambridge Quarterly of Healthcare Ethics 32 (2):202-215.
    Many ethical theorists believe that a given distribution of healthcare is morally justified only if (1) it is cost-effective and (2) it does not discriminate against older adults and disabled people. However, if (3) cost-effectiveness involves maximizing the number of quality-adjusted life-years (QALYs) added by a given unit of healthcare resource, or cost, it seems the pursuit of cost-effectiveness will inevitably discriminate against older adults and disabled patients. I show why this trilemma is harder to escape than some theorists think. (...)
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  • The Challenge of Nonconfrontational Ethics.John Harris - 2011 - Cambridge Quarterly of Healthcare Ethics 20 (2):204-215.
    Matti Häyry’s new book is deliberately challenging; it tells six contemporary bioethicists, and all who share their methodologies or even their general approach, that they have got it badly wrong. From the striking photograph of Häyry himself on the front cover to the very last line, the genetic challenge is issued and elaborated. Häyry has divided his protagonists into three pairs, of which I find myself a member, and this makes responding a duty as well as a pleasure. Although I (...)
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  • Trust and Altruism--Organ Distribution Scandals: Do They Provide Good Reasons to Refuse Posthumous Donation?A. Dufner & J. Harris - 2015 - Journal of Medicine and Philosophy 40 (3):328-341.
    A recent organ distribution scandal in Germany raises questions of general importance on which many thousands of lives may well depend. The scandal in Germany has produced reactions that are likely to occur whenever and wherever distribution irregularities occur and become public knowledge. After it had become known that physicians in three German hospitals were in the habit of manipulating records in order to fast-track their patients’ cases, the country experienced a decrease of available organs by a staggering 40% in (...)
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  • An empirical ethics study of the coherence of NICE technology appraisal policy and its implications for moral justification.Victoria Charlton & Michael DiStefano - 2024 - BMC Medical Ethics 25 (1):1-22.
    Background As the UK’s main healthcare priority-setter, the National Institute for Health and Care Excellence (NICE) has good reason to want to demonstrate that its decisions are morally justified. In doing so, it has tended to rely on the moral plausibility of its principle of cost-effectiveness and the assertion that it has adopted a fair procedure. But neither approach provides wholly satisfactory grounds for morally defending NICE’s decisions. In this study we adopt a complementary approach, based on the proposition that (...)
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  • Quality of life is a process not an outcome.Leah McClimans & John P. Browne - 2012 - Theoretical Medicine and Bioethics 33 (4):279-292.
    Quality improvement mechanisms increasingly use outcome measures to evaluate health care providers. This move toward outcome measures is a radical departure from the traditional focus on process measures. More radical still is the proposal to shift from relatively simple and proximal measures of outcome, such as mortality, to complex outcomes, such as quality of life. While the practical, scientific, and ethical issues associated with the use of outcomes such as mortality and morbidity to compare health care providers have been well (...)
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  • Not a NICE fallacy: a reply to Dr Quigley.K. Claxton & A. J. Culyer - 2008 - Journal of Medical Ethics 34 (8):598-601.
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  • An fMRI investigation of moral cognition in healthcare decision making.Timothy L. Hodgson, Lisa J. Smith, Paul Anand & Abdelmalek Benattayallah - 2015 - Journal of Neuroscience Psychology and Economics 8 (2):116-133.
    This study used fMRI to investigate the neural substrates of moral cognition in health resource allocation decision problems. In particular, it investigated the cognitive and emotional processes that underpin utilitarian approaches to health care rationing such as Quality Adjusted Life Years. Participants viewed hypothetical medical and nonmedical resource allocation scenarios which described equal or unequal allocation of resources to different groups. In addition, participants were assigned to 1 of 2 treatments in which they either did or did not receive advanced (...)
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  • Current knowledge in moral cognition can improve medical ethics.S. Tassy, P. Le Coz & B. Wicker - 2008 - Journal of Medical Ethics 34 (9):679-682.
    Physicians frequently face ethical dilemmas when caring for patients. To help them to cope with these, biomedical ethics aims to implement moral norms for particular problems and contexts. As a means of studying the cognitive and neurobiological features underlying the respect for these norms, moral cognitive neuroscience could help us to understand and improve ethical questioning. The article reviews recent developments in the field and presents neurobiological arguments to highlight why some moral rules are universally shared and why some ethical (...)
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  • The ethics of attaching research conditions to access to new health technologies.Stephen Holland & Tony Hope - 2012 - Journal of Medical Ethics 38 (6):366-371.
    Decisions on which new health technologies to provide are controversial because of the scarcity of healthcare resources, the competing demands of payers, providers and patients and the uncertainty of the evidence base. Given this, additional information about new health technologies is often considered valuable. One response is to make access to a new health technology conditional on further research. Access can be restricted to patients who participate in a research study, such as a randomised controlled trial; alternatively, a new treatment (...)
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  • Wickedness or folly? The ethics of NICE's decisions.K. Claxton - 2006 - Journal of Medical Ethics 32 (7):373-377.
    A rebuttal is provided to each of the arguments adduced by John Harris, an Editor-in-Chief of the Journal of Medical Ethics, in two editorials in the journal in support of the view that National Institute for Health and Clinical Excellence’s procedures and methods for making recommendations about healthcare procedures for use in the National Health Service in England and Wales are the product of “wickedness or folly or more likely both”, “ethically illiterate as well as socially divisive”, responsible for the (...)
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  • Evidence, ethics and inclusion: a broader base for NICE. [REVIEW]Stephen Wilmot - 2011 - Medicine, Health Care and Philosophy 14 (2):111-121.
    The National Institute for Health and Clinical Excellence (hereafter NICE) was created in 1998 to give guidance on which treatments should be provided by the British National Health Service, and to whom. So it has a crucial role as an agent of distributive justice. In this paper I argue that it is failing to adequately explain and justify its decisions in the public arena, particularly in terms of distributive justice; and that this weakens its legitimacy, to the detriment of the (...)
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