In recent years, the biomedical field has witnessed the emergence of novel tools and modelling techniques driven by the rise of the so-called Big Data. In this paper, we address the issue of predictability in biomedical Big Data models of cancer patients, with the aim of determining the extent to which computationally driven predictions can be implemented by medical doctors in their clinical practice. We show that for a specific class of approaches, called k-Nearest Neighbour algorithms, the ability to draw (...) predictive inferences relies on a geometrical, or topological, notion of similarity encoded in a well-defined metric, which determines how close the characteristics of distinct patients are on average. We then discuss the conditions under which the relevant models can yield reliable and trustworthy predictive outcomes. (shrink)

Empiricist modal epistemologies can be attractive, but are often limited in the range of modal knowledge they manage to secure. In this paper, I argue that one such account – similarity-based modal empiricism – can be extended to also cover justification of many scientifically interesting possibility claims. Drawing on recent work on modelling in the philosophy of science, I suggest that scientific modelling is usefully seen as the creation and investigation of relevantly similar epistemic counterparts of real target systems. On (...) the basis of experiential knowledge of what is actually the case with the models, one can draw justified conclusions about what is de re possible for the target systems. (shrink)

This paper constitutes a radical departure from the existing philosophical literature on models, modeling-practices, and model-based science. I argue that the various entities and practices called 'models' and 'modeling-practices' are too diverse, too context-sensitive, and serve too many scientific purposes and roles, as to allow for a general philosophical analysis. From this recognition an alternative view emerges that I shall dub model anarchism.

In this paper, we explore an under-investigated question concerning the class of formal models that aim at providing normative guidance. We call such models normative models. In particular, we examine the question of how normative models can successfully exert normative guidance. First, we highlight the absence of a discussion of this question – which is surprising given the extensive debate about the success conditions of descriptive models – and motivate its importance. Second, we introduce and discuss two potential accounts of (...) the success conditions of normative models. Our tentative conclusion is that the second account is more promising. (shrink)

Highly idealized models may serve various epistemic functions, notably explanation, in virtue of representing the world. Inferentialism provides a prima facie compelling characterization of what constitutes the representation relation. In this paper, I argue that what I call factive inferentialism does not provide a satisfactory solution to the puzzle of model-based—factive—explanation. In particular, I show that making explanatory counterfactual inferences is not a sufficient guide for accurate representation, factivity, or realism. I conclude by calling for a more explicit specification of (...) model-world mismatches and properties imputation. (shrink)

Veritism, the position that truth is necessary for epistemic acceptability, seems to be in tension with the observation that much of our best science is not, strictly speaking, true when interpreted literally. This generates a paradox: truth is necessary for epistemic acceptability; the claims of science have to be taken literally; much of what science produces is not literally true and yet it is acceptable. We frame Elgin’s project in True Enough as being motivated by, and offering a particular resolution (...) to, this paradox. We discuss the paradox with a focus on scientific models and argue that there is another resolution available which is compatible with retaining veritism: rejecting the idea that scientific models should be interpreted literally. (shrink)

Drawing on ‘interpretational’ accounts of scientific representation, I argue that the use of so-called ‘toy models’ provides no particular philosophical puzzle. More specifically; I argue that once one gives up the idea that models are accurate representations of their targets only if they are appropriately similar, then simple and highly idealized models can be accurate in the same way that more complex models can be. Their differences turn on trading precision for generality, but, if they are appropriately interpreted, toy models (...) should nevertheless be considered accurate representations. A corollary of my discussion is a novel way of thinking about idealization more generally: idealized models may distort features of their targets, but they needn’t misrepresent them. (shrink)

This paper argues that an important type of experiment-target inference, extrapolating causal effects, requires models to be successful. Focusing on extrapolation in Evidence-Based Policy, it is ar...

Science provides us with representations of atoms, elementary particles, polymers, populations, genetic trees, economies, rational decisions, aeroplanes, earthquakes, forest fires, irrigation systems, and the world’s climate. It's through these representations that we learn about the world. This entry explores various different accounts of scientific representation, with a particular focus on how scientific models represent their target systems. As philosophers of science are increasingly acknowledging the importance, if not the primacy, of scientific models as representational units of science, it's important to (...) stress that how they represent plays a fundamental role in how we are to answer other questions in the philosophy of science. This entry begins by disentangling ‘the’ problem of scientific representation, before critically evaluating the current options available in the literature. (shrink)