The dissemination of models across disciplinary lines has become a phenomenon of interest to philosophers of science. To account for this phenomenon, philosophers have invented two units of analysis. The first identifies to the thing that transfers, model templates. The second identifies the thing to which transferable templates apply, landing zones. There exists a dynamic between the thing that is transferred and the thing to which transferrable templates apply. The use of a transferable template in a new domain requires reconception (...) of domain-specific phenomena. This paper examines two cases of model transfer, the use of the ideal gas law in biology by R.A. Fisher and the use of the virial theorem in chemistry by Richard Bader. These two stories of model transfer in biology and chemistry indicate a dimension to conceptual progress related to this dynamic. Using discourse on model transfer affords philosophers a novel approach for depicting the invention of, for instance, chemical concepts and resulting disputes. (shrink)

The dissemination of models across disciplinary lines has become a phenomenon of interest to philosophers of science. To account for this phenomenon, philosophers have invented two units of analysis. The first identifies to the thing that transfers, model templates. The second identifies the thing to which transferable templates apply, landing zones. There exists a dynamic between the thing that is transferred and the thing to which transferrable templates apply. The use of a transferable template in a new domain requires reconception (...) of domain-specific phenomena. This paper examines two cases of model transfer, the use of the ideal gas law in biology by R.A. Fisher and the use of the virial theorem in chemistry by Richard Bader. These two stories of model transfer in biology and chemistry indicate a dimension to conceptual progress related to this dynamic. Using discourse on model transfer affords philosophers a novel approach for depicting the invention of, for instance, chemical concepts and resulting disputes. (shrink)

Network theory is applied across the sciences to study phenomena as diverse as the spread of SARS, the topology of the cell, the structure of the Internet and job search behaviour. Underlying the study of networks is graph theory. Whether the graph represents a network of neurons, cells, friends or firms, it displays features that exclusively depend on the mathematical properties of the graph itself. However, the way in which graph theory is implemented to the modelling of networks differs significantly (...) across scientific fields. This article compares the economics variant of network theory with those of other fields. It shows how the methodology employed by economists to model networks is shaped by two explanatory desiderata: that the explanandum phenomenon is based on micro-economic foundations and that the explanation is general. (shrink)

The picture of synthetic biology as a kind of engineering science has largely created the public understanding of this novel field, covering both its promises and risks. In this paper, we will argue that the actual situation is more nuanced and complex. Synthetic biology is a highly interdisciplinary field of research located at the interface of physics, chemistry, biology, and computational science. All of these fields provide concepts, metaphors, mathematical tools, and models, which are typically utilized by synthetic biologists by (...) drawing analogies between the different fields of inquiry. We will study analogical reasoning in synthetic biology through the emergence of the functional meaning of noise, which marks an important shift in how engineering concepts are employed in this field. The notion of noise serves also to highlight the differences between the two branches of synthetic biology: the basic science-oriented branch and the engineering-oriented branch, which differ from each other in the way they draw analogies to various other fields of study. Moreover, we show that fixing the mapping between a source domain and the target domain seems not to be the goal of analogical reasoning in actual scientific practice. (shrink)

ABSTRACT Is there something specific about modelling that distinguishes it from many other theoretical endeavours? We consider Michael Weisberg’s thesis that modelling is a form of indirect representation through a close examination of the historical roots of the Lotka–Volterra model. While Weisberg discusses only Volterra’s work, we also study Lotka’s very different design of the Lotka–Volterra model. We will argue that while there are elements of indirect representation in both Volterra’s and Lotka’s modelling approaches, they are largely due to two (...) other features of contemporary model construction processes that Weisberg does not explicitly consider: the methods-drivenness and outcome-orientedness of modelling. 1Introduction 2Modelling as Indirect Representation 3The Design of the Lotka–Volterra Model by Volterra 3.1Volterra’s method of hypothesis 3.2The construction of the Lotka–Volterra model by Volterra 4The Design of the Lotka–Volterra Model by Lotka 4.1Physical biology according to Lotka 4.2Lotka’s systems approach and the Lotka–Volterra model 5Philosophical Discussion: Strategies and Tools of Modelling 5.1Volterra’s path from the method of isolation to the method of hypothesis 5.2The template-based approach of Lotka 5.3Modelling: methods-driven and outcome-oriented 6Conclusion. (shrink)

Synthetic biology is often understood in terms of the pursuit for well-characterized biological parts to create synthetic wholes. Accordingly, it has typically been conceived of as an engineering dominated and application oriented field. We argue that the relationship of synthetic biology to engineering is far more nuanced than that and involves a sophisticated epistemic dimension, as shown by the recent practice of synthetic modeling. Synthetic models are engineered genetic networks that are implanted in a natural cell environment. Their construction is (...) typically combined with experiments on model organisms as well as mathematical modeling and simulation. What is especially interesting about this combinational modeling practice is that, apart from greater integration between these different epistemic activities, it has also led to the questioning of some central assumptions and notions on which synthetic biology is based. As a result synthetic biology is in the process of becoming more “biology inspired.”. (shrink)

Weisberg (2006) and Godfrey-Smith (2006, 2009) distinguish between two forms of theorising: data-driven ‘abstract direct representation’ and modeling. The key difference is that when using a data-driven approach, theories are intended to represent specific phenomena, so directly represent them, while models may not be intended to represent anything, so represent targets indirectly, if at all. The aim here is to compare and analyse these practices, in order to outline an account of model-based theorising that involves direct representational relationships. This is (...) based on the way that computational templates Humphreys (2002, 2004) are now used in cognitive neuroscience, and draws on the dynamic and tentative process of any kind of theory construction, and the idea of partial, purpose-relative representation. (shrink)

There continues to be significant confusion about the goals, scope, and nature of modelling practice in neuroeconomics. This article aims to dispel some such confusion by using one of the most recent critiques of neuroeconomic modelling as a foil. The article argues for two claims. First, currently, for at least some economic model of choice behaviour, the benefits derivable from neurally informing an economic model do not involve special tractability costs. Second, modelling in neuroeconomics is best understood within Marr’s three-level (...) of analysis framework and in light of a co-evolutionary research ideology. The first claim is established by elucidating the relationship between the tractability of a model, its descriptive accuracy, and its number of variables. The second claim relies on an explanation of what it can take to neurally inform an economic model of choice behaviour. 1 Introduction2 Neurally Informed Models of Choice: A Case Study2.1 A case study on risk-sensitive choice2.1.1 Target and modelling framework2.1.2 Research question and hypotheses2.1.3 Competitive models of risk-sensitive behaviour2.1.4 Model-based fMRI: from economics to brains and back2.2 Neurally informed modelling3 Tractability: When Does Size Matter?4 Neural Integration and the Co-evolutionary Research Ideology5 Conclusion. (shrink)

While many recent accounts of scientific representation have given a central role to the agency and intentions of scientists in explaining representation, they have left these agential concepts unanalyzed. An account of scientific, representational actions will be a useful piece in offering a more complete account of the practice of representation in science. Drawing on an Anscombean approach to the nature of intentional actions, the Means-End Account of Scientific, Representational Actions describes three features of scientific, representational actions: the final description (...) in the means-end ordering of descriptions is some scientific aim; that interaction with a vehicle distinct from its target stands as an earlier description which is ordered toward the final description as means to end; and the means-end structure is licensed by scientific practice. After describing each of the components of the Means-End Account in greater detail through the example of the representational use of a mathematical model, I explain how it can demarcate scientific, representational actions from other sorts of actions. I close by describing some payoffs of the account, showing how it contributes to a more thorough understanding of the practice of representation in science and how it can be of use in understanding the close connection between representation and other forms of scientific activity. (shrink)

While many recent accounts of scientific representation have given a central role to the agency and intentions of scientists in explaining representation, they have left these agential concepts unanalyzed. An account of scientific, representational actions will be a useful piece in offering a more complete account of the practice of representation in science. Drawing on an Anscombean approach to the nature of intentional actions, the Means-End Account of Scientific, Representational Actions describes three features of scientific, representational actions: (I) the final (...) description in the means-end ordering of descriptions is some scientific aim; (II) that interaction with a vehicle distinct from its target stands as an earlier description which is ordered toward the final description as means to end; and (III) the means-end structure is licensed by scientific practice. After describing each of the components of the Means-End Account in greater detail through the example of the representational use of a mathematical model, I explain how it can demarcate scientific, representational actions from other sorts of actions. I close by describing some payoffs of the account, showing how it contributes to a more thorough understanding of the practice of representation in science and how it can be of use in understanding the close connection between representation and other forms of scientific activity. (shrink)

Callender and Cohen argue that there is no need for a special account of the constitution of scientific representation. I argue that scientific representation is communal and therefore deeply tied to the practice in which it is embedded. The communal nature is accounted for by licensing, the activities of scientific practice by which scientists establish a representation. A case study of the Lotka-Volterra model reveals how licensure is a constitutive element of the representational relationship. Thus, any account of the constitution (...) of scientific representation must account for licensing, meaning that there is a special problem of scientific representation. (shrink)

It is widely argued that the skills of scientific expertise are tacit, meaning that they are difficult to study. In this essay, I draw on work from the philosophy of action about the nature of skills to show that there is another access point for the study of skills—namely, skill transmission in science education. I will begin by outlining Small’s Aristotelian account of skills, including a brief exposition of its advantages over alternative accounts of skills. He argues that skills exist (...) in a sort of life cycle between learning, practicing, and transmitting, which provides reasons to think that we should pay close attention to the way skills are transmitted in teaching and learning. To demonstrate how a study of skill transmittance can be revealing about the nature of skills in expertise, I explore an example—what I identify as the skill of tension-balancing in model-building. After describing the skill, I briefly examine two case studies from the science education literature that reveal insights about the skill of tension-balancing as it functions in the practice of model-building. (shrink)

One of the most conspicuous features of contemporary modeling practices is the dissemination of mathematical and computational methods across disciplinary boundaries. We study this process through two applications of the Ising model: the Sherrington-Kirkpatrick model of spin glasses and the Hopfield model of associative memory. The Hopfield model successfully transferred some basic ideas and mathematical methods originally developed within the study of magnetic systems to the field of neuroscience. As an analytical resource we use Paul Humphreys's discussion of computational and (...) theoretical templates. We argue that model templates are crucial for the intra- and interdisciplinary theoretical transfer. A model template is an abstract conceptual idea associated with particular mathematical forms and computational methods. (shrink)