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  1. Descriptive understanding and prediction in COVID-19 modelling.Johannes Findl & Javier Suárez - 2021 - History and Philosophy of the Life Sciences 43 (4):1-31.
    COVID-19 has substantially affected our lives during 2020. Since its beginning, several epidemiological models have been developed to investigate the specific dynamics of the disease. Early COVID-19 epidemiological models were purely statistical, based on a curve-fitting approach, and did not include causal knowledge about the disease. Yet, these models had predictive capacity; thus they were used to ground important political decisions, in virtue of the understanding of the dynamics of the pandemic that they offered. This raises a philosophical question about (...)
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  • The Network Theory of Psychiatric Disorders: A Critical Assessment of the Inclusion of Environmental Factors.Nina S. de Boer, Leon C. de Bruin, Jeroen J. G. Geurts & Gerrit Glas - 2021 - Frontiers in Psychology 12.
    Borsboom and colleagues have recently proposed a “network theory” of psychiatric disorders that conceptualizes psychiatric disorders as relatively stable networks of causally interacting symptoms. They have also claimed that the network theory should include non-symptom variables such as environmental factors. How are environmental factors incorporated in the network theory, and what kind of explanations of psychiatric disorders can such an “extended” network theory provide? The aim of this article is to critically examine what explanatory strategies the network theory that includes (...)
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  • The Directionality of Topological Explanations.Daniel Kostić & Kareem Khalifa - 2021 - Synthese (5-6):14143-14165.
    Proponents of ontic conceptions of explanation require all explanations to be backed by causal, constitutive, or similar relations. Among their justifications is that only ontic conceptions can do justice to the ‘directionality’ of explanation, i.e., the requirement that if X explains Y , then not-Y does not explain not-X . Using topological explanations as an illustration, we argue that non-ontic conceptions of explanation have ample resources for securing the directionality of explanations. The different ways in which neuroscientists rely on multiplexes (...)
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  • Decoupling Topological Explanations From Mechanisms.Daniel Kostic & Kareem Khalifa - forthcoming - Philosophy of Science:1-39.
    We provide three innovations to recent debates about whether topological or “network” explanations are a species of mechanistic explanation. First, we more precisely characterize the requirement that all topological explanations are mechanistic explanations and show scientific practice to belie such a requirement. Second, we provide an account that unifies mechanistic and non-mechanistic topological explanations, thereby enriching both the mechanist and autonomist programs by highlighting when and where topological explanations are mechanistic. Third, we defend this view against some powerful mechanist objections. (...)
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  • Using Network Models in Person-Centered Care in Psychiatry: How Perspectivism Could Help To Draw Boundaries.Nina de Boer, Daniel Kostić, Marcos Ross, Leon de Bruin & Gerrit Glas - 2022 - Frontiers in Psychiatry, Section Psychopathology 13 (925187).
    In this paper, we explore the conceptual problems arising when using network analysis in person- centered care (PCC) in psychiatry. Personalized network models are potentially helpful tools for PCC, but we argue that using them in psychiatric practice raises boundary problems, i.e., problems in demarcating what should and should not be included in the model, which may limit their ability to provide clinically-relevant knowledge. Models can have explanatory and representational boundaries, among others. We argue that we can make more explicit (...)
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  • Integrating Philosophy of Understanding with the Cognitive Sciences.Kareem Khalifa, Farhan Islam, J. P. Gamboa, Daniel Wilkenfeld & Daniel Kostić - 2022 - Frontiers in Systems Neuroscience 16.
    We provide two programmatic frameworks for integrating philosophical research on understanding with complementary work in computer science, psychology, and neuroscience. First, philosophical theories of understanding have consequences about how agents should reason if they are to understand that can then be evaluated empirically by their concordance with findings in scientific studies of reasoning. Second, these studies use a multitude of explanations, and a philosophical theory of understanding is well suited to integrating these explanations in illuminating ways.
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  • Unifying the Essential Concepts of Biological Networks: Biological Insights and Philosophical Foundations.Daniel Kostic, Claus Hilgetag & Marc Tittgemeyer - forthcoming - Philosophical Transactions of the Royal Society B: Biological Sciences.
    Over the last decades, network-based approaches have become highly popular in diverse fields of biology, including neuroscience, ecology, molecular biology and genetics. While these approaches continue to grow very rapidly, some of their conceptual and methodological aspects still require a programmatic foundation. This challenge particularly concerns the question of whether a generalized account of explanatory, organisational and descriptive levels of networks can be applied universally across biological sciences. To this end, this highly interdisciplinary theme issue focuses on the definition, motivation (...)
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