The concept of the cortical column refers to vertical cell bands with similar response properties, which were initially observed by Vernon Mountcastle’s mapping of single cell recordings in the cat somatic cortex. It has subsequently guided over 50 years of neuroscientific research, in which fundamental questions about the modularity of the cortex and basic principles of sensory information processing were empirically investigated. Nevertheless, the status of the column remains controversial today, as skeptical commentators proclaim that the vertical cell bands are (...) a functionally insignificant by-product of ontogenetic development. This paper inquires how the column came to be viewed as an elementary unit of the cortex from Mountcastle’s discovery in 1955 until David Hubel and Torsten Wiesel’s reception of the Nobel Prize in 1981. I first argue that Mountcastle’s vertical electrode recordings served as criteria for applying the column concept to electrophysiological data. In contrast to previous authors, I claim that this move from electrophysiological data to the phenomenon of columnar responses was concept-laden, but not theory-laden. In the second part of the paper, I argue that Mountcastle’s criteria provided Hubel Wiesel with a conceptual outlook, i.e. it allowed them to anticipate columnar patterns in the cat and macaque visual cortex. I argue that in the late 1970s, this outlook only briefly took a form that one could call a ‘theory’ of the cerebral cortex, before new experimental techniques started to diversify column research. I end by showing how this account of early column research fits into a larger project that follows the conceptual development of the column into the present. (shrink)

In contemporary human brain mapping, it is commonly assumed that the “mind is what the brain does”. Based on that assumption, task-based imaging studies of the last three decades measured differences in brain activity that are thought to reflect the exercise of human mental capacities (e.g., perception, attention, memory). With the advancement of resting state studies, tractography and graph theory in the last decade, however, it became possible to study human brain connectivity without relying on cognitive tasks or constructs. It (...) therefore is currently an open question whether the assumption that “the mind is what the brain does” is an indispensable working hypothesis in human brain mapping. This paper argues that the hypothesis is, in fact, dispensable. If it is dropped, researchers can “meet the brain on its own terms” by searching for new, more adequate concepts to describe human brain organization. Neuroscientists can establish such concepts by conducting exploratory experiments that do not test particular cognitive hypotheses. The paper provides a systematic account of exploratory neuroscientific research that would allow researchers to form new concepts and formulate general principles of brain connectivity, and to combine connectivity studies with manipulation methods to identify neural entities in the brain. These research strategies would be most fruitful if applied to the mesoscopic scale of neuronal assemblies, since the organizational principles at this scale are currently largely unknown. This could help researchers to link microscopic and macroscopic evidence to provide a more comprehensive understanding of the human brain. The paper concludes by comparing this account of exploratory neuroscientific experiments to recent proposals for large-scale, discovery-based studies of human brain connectivity. (shrink)

The theory-theory of human uniqueness posits that the capacity to theorize, in a way strongly analogous to theorizing in scientific practice, was a key innovation in the hominid lineage and was responsible for many of our unique cognitive traits. One of the central arguments that its proponents have used to support the claim that animals are not theorists, the logical problem, bears strong similarities to Hempel's theoretician's dilemma, which purports to show that theories are unnecessary. This similarity threatens to undermine (...) both the claim that theorizing serves a unique, adaptive role in human cognition and our ability to test for the presence of theories. I examine two historical responses to the theoretician's dilemma and argue that they open up strategies for experimentally testing for theoretical ability in other animals. (shrink)

In this article, I investigate the possibility of reconciling a radically disenchanted scientific naturalism in ontology with the unconditional and non-instrumental character of the moral point of view. My point of departure will be Sellars’s philosophy, which attempts to satisfy both those, seemingly unreconcilable, demands at once. I shall argue that there is a tension between those two demands that finds expression both at the theoretical and practical level, and which is not adequately resolved from a strictly Sellarsian perspective. I (...) will then develop a neo-Sellarsian framework, close to the spirit—if not the letter—of Sellars’s philosophy, which, as I will suggest, can live up to this task. This solution depends (1) on insisting on both the semantic irreducibility and explanatory reducibility of moral normativity to non-normative facts, while simultaneously acknowledging that those two dimensions mutually presuppose and support on another, and (2) on recognizing that the instrumental facets of theoretical-scientific rationality need not imply a coercive attitude toward nature, ourselves, and others. (shrink)

The purpose of this paper is to evaluate Lange’s argument in support of Sellars’ scientific realism, which, if successful, surprisingly, undermines Sellars’ scientia mensura principle and justifies the anti-Sellarsian view to the effect that certain domains of discourse which use irreducibly normative descriptions and explanations are explanatorily autonomous. It will be argued that Lange’s argument against the layer-cake view is not strictly speaking Sellarsian, since Lange interprets Sellars’ argument in an overly abstract or formal manner. Moreover, I will suggest that, (...) within a properly Sellarsian context, Lange’s argument against the layer-cake picture can actually be used for quite un- Langean purposes, namely in order to show that folk- psychological descriptions and explanations are not if fact autonomous. However, Lange could insist that his reconstruction of Sellars’ argument is substantially correct and he does have the resources to do so. I will propose that the substantial issue between Lange and Sellars turns on their different views on the function of ceteris-paribus clauses, and ultimately, on issues about the unity of science. Finally, it will be suggested that the Sellarsian framework for tackling these issues constitutes a viable alternative to Lange’s picture of theoretical explanation, while at the same time incorporating be the sound insights of the latter. (shrink)