This essay analyzes the ways in which, in his Nova de Universis Philosophia, Francesco Patrizi uses, adopts, and, in some cases, rejects the Stoic philosophical tradition. Although, at first glance, most of Patrizi’s remarks on Stoicism and Stoic understanding of nature are critical – as this article demonstrates – he widely relied on Stoic teaching that he sought to combine with Neoplatonism and the prisca theologia doctrine.