This paper explores the options available to the anti-realist to defend a Quinean empirical under-determination thesis using examples of dualities. I first explicate a version of the empirical under-determination thesis that can be brought to bear on theories of contemporary physics. Then I identify a class of examples of dualities that lead to empirical under-determination. But I argue that the resulting under-determination is benign, and is not a threat to a cautious scientific realism. Thus dualities are not new ammunition for (...) the anti-realist. The paper also shows how the number of possible interpretative options about dualities that have been considered in the literature can be reduced, and suggests a general approach to scientific realism that one may take dualities to favour. (shrink)