Johann Friedrich Blumenbach is widely known as the father of German vitalism and his notion of Bildungstrieb, or nisus formativus, has been recognized as playing a key role in the debates about generation in German-speaking countries around 1800. On the other hand, Caspar Friedrich Wolff was the first to employ a vitalist notion, namely that of vis essentialis, in the explanatory framework of epigenetic development. Is there a difference between Wolff’s vis essentialis and Blumenbach’s nisus formativus? How does this difference (...) influence their overall understanding of the epigenetic process? The paper aims to provide an answer to these questions through the analysis of a little-known document, which contributes to shed light on a crucial chapter of the German life sciences in the late eighteenth-century, namely the decisive phase of the process that led to the formalization of biology as a unified field of inquiry at the beginning of the nineteenth century. (shrink)

John Richardson (2002, 2004) argues that Nietzsche’s use of teleological notions, such as the “will to power” and psychological “drives,” can be naturalized within the Darwinian framework of natural selection. Although this ambitious project has merit, the Darwinian framework does not provide the strong teleology necessary to interpret Nietzsche’s explanatory project. Examining the logic of selection, the conceptual limitations on biological functions, and the evidential demands that must be met to deploy evolutionary theory show that Nietzsche’s explanatory project does not (...) cohere with the Darwinian framework. Thus, coherence with currently accepted evolutionary theory should not constrain the philosophical project of interpretation in this case. (shrink)

Franco Andrea Bonelli, a disciple of Lamarck, was one of the few naturalists who taught and disseminated transformism in Italy in the early nineteenth century. The explanation of the history of life on Earth offered by Lamarck’s theory was at odds with the Genesis narrative, while the issue of man’s place in nature raised heated debates. Bonelli sought to reconcile science and religion through his original interpretation of the variability of species, but he also focused on anthropological subjects. Following Blumenbach’s (...) studies, he investigated the differences within the human species and explored the topic of humans’ alleged superiority over animals. The origin of human beings, their history, and their relationship with the rest of life were thus read in light of transformism. According to Bonelli, such questions would not do irreparable damage to the new theory. On the contrary, he considered evolution not only acceptable but even necessary to protect the Holy Texts from certain dangerous trends in anthropological and zoological research. (shrink)

In this paper we examine aspects of Canguilhem’s philosophy of biology, concerning the knowledge of life and its consequences on science and vitalism. His concept of life stems from the idea of a living individual, endowed with creative subjectivity and norms, a Kantian view which “disconcerts logic”. In contrast, two different approaches ground naturalistic perspectives to explore the logic of life and the logic of the living individual in the 1970s. Although Canguilhem is closer to the second, there are divergences; (...) for example, unlike them, he does not dismiss vitalism, often referring to it in his work and even at times describing himself as a vitalist. The reason may lie in their different views of science. (shrink)

Iceland has not been known as a contributor to the history of science. This small nation in the North-Atlantic has only in recent decades made its mark on international science. But the Icelandic naturalist Thorvaldur Thoroddsen (1855-1921) is an exception to this generalisation, for he was well known at the turn of the 20th century in Europe and America for his research on the geography and geology of Iceland. Though Thoroddsen's contribution to these sciences is of great interest there is (...) another very interesting side to his career. This is his transformation from "mechanist" to "vitalist," which is the main focus of this paper. Thoroddsen, who began his career as a follower of Darwinism and Haeckelian monism, started to express his worries about materialism in society in 1902 culminating in a full-fledged denial of materialism in politics and science in 1910. Thoroddsen's transformation is in its nature a very complex process, but overall it can be traced to his view that materialism was destroying the Danish and Icelandic societies. In the years before 1902 Thoroddsen was a monistic atheist, relatively liberal in his politics, a firm believer in the power of the natural sciences, and considered the laws of physics the key to human progress. His views were strikingly similar to the ones Haeckel expounded in "The Riddle of the Universe" (1899), whose reception in Germany is explored in this paper in order to contextualise Thoroddsen's transformation. Between 1902 and 1910, however, Thoroddsen rejected this worldview in favour of conservative politics and ontological dualism, becoming a staunch believer in a higher, godly, authority. The theories of Darwin and Haeckel were now obsolete and needed to be replaced by the idea of purpose, direction and the final goal of life (Teleology). In order to understand Thoroddsen's transformation, I focus on the interaction of scientific knowledge, politics and other cultural issues in his writings. This is done by looking at Thoroddsen's views on biology, on the natural sciences in general, and on politics as published in Icelandic articles, manuscripts and letters in the period 1872 to 1910. I show that the transformation was due to influences from the German holistic movement, Thoroddsen's engagement with the Royal elite in Denmark and its political concerns, new developments in physics, and from personal traumas and professional disappointments. I also show that Thoroddsen's transformation seems to be a good example of the social shaping of scientific knowledge. (shrink)

At the end of the nineteenth century, approaches from experimental physiology made inroads into embryological research. A new generation of embryologists felt urged to study the mechanisms of organ formation. This new program, most prominently defended by Wilhelm Roux, was called Entwicklungsmechanik. Named variously as “causal embryology”, “physiological embryology” or “developmental mechanics”, it catalyzed the movement of embryology from a descriptive science to one exploring causal mechanisms. This article examines the specific scientific and epistemological meaning of the mechanistic approaches of (...) embryological development by focusing on Wilhelm His’ histogenetic work. Roux was neither the first, nor the only one to argue for an experimental exploration of causes in embryology. At the time of Roux, physiological explanations of the genesis of the anatomical forms were developing in parallel, not only in German-speaking countries, but in France, Switzerland and English-speaking countries as well. The experimental approach and the cellular descriptions of embryogenesis were already omni-present when Roux proposed his Entwicklungsmechanik. However, these approaches remained disjointed. It appears that it was Wilhelm His who first succeeded in combining the question of the causal factors determining epigenesis, which was closely connected with experimentation on, and cellular descriptions of, development, in a coherent and concrete synthesis, making him one of the true initiators of the developmental mechanics. (shrink)

Stem cells did not become a proper research object until the 1960 s. Yet the term and the basic mind-set—namely the conception of single undifferentiated cells, be they embryonic or adult, as the basic units responsible for a directed process of development, differentiation and increasing specialisation—were already in place at the end of the nineteenth century and then transmitted on a non-linear path in the form of tropes and diagrams. Ernst Haeckel and August Weismann played a special role in this (...) story. The first coined the term Stammzelle (stem cell), the second was the author of the first cellular stem-tree diagram. Even today, I shall argue, the understanding of stem cells, especially the popular perception, is to a large extent a Haeckelian–Weismannian one. After having demonstrated this, by analysing the terminology, in this essay I will focus on the use of cytogenetic tree diagrams between 1892 and 1925 and on the tacit understanding of stem cells that they transmit. (shrink)

Defending Robert Rosen’s claim that in every confrontation between physics and biology it is physics that has always had to give ground, it is shown that many of the most important advances in mathematics and physics over the last two centuries have followed from Schelling’s demand for a new physics that could make the emergence of life intelligible. Consequently, while reductionism prevails in biology, many biophysicists are resolutely anti-reductionist. This history is used to identify and defend a fragmented but progressive (...) tradition of anti-reductionist biomathematics. It is shown that the mathematicoephysico echemical morphology research program, the biosemiotics movement, and the relational biology of Rosen, although they have developed independently of each other, are built on and advance this antireductionist tradition of thought. It is suggested that understanding this history and its relationship to the broader history of post-Newtonian science could provide guidance for and justify both the integration of these strands and radically new work in post-reductionist biomathematics. (shrink)

While historians of the microscope currently consider that no programme of microscopy took place during the Enlightenment, the thesis challenges this view and aims at showing when and where microscopes were used as research tools. The focus of the inquiry is the research on microscopic animalcules and the relationship of European microscope making and practices of microscopy with topical trends of the industrial revolution, such as quantification. Three waves of research are characterised for the research on animalcules in the Enlightenment: (...) 1. seventeenth-century observations on animalcules crowned by Louis Joblot's 1718 works in the milieu of Paris Académie royale des sciences, 2. mid eighteenth-century observations and experiments on polyps and animalcules (Trembley, Baker and Hill) and, 3. between 1760 and 1790, OF Müller's establishment of the systematics of infusoria in Denmark and Germany. (shrink)

Despite the radical importance of embryology in the development of organi- cism, developmental biology remains philosophically underexplored as a theoretical and empirical resource to clarify the nature of organisms. This paper discusses how embryology can help develop the organisational definition of the organism as a differentiated, function- ally integrated, and autonomous system. I distinguish two conceptions of development in the organisational tradition that yield two different conceptions of the organism: the life- history view claims that organisms can be considered as (...) such during their whole ontogeny; the constitutive view distinguishes two periods in the life history, a period of generation and a period of self-maintenance of a constitutive organisation. Arguing in favour of the con- stitutive view, it will be claimed that the organisational criteria for the definition of organ- ism (i.e., differentiation, functional integration, and autonomy) can only be applied to the developmental system when it has entered the period of self-maintenance of a constitutive organisation. under the light of current research in developmental biology, it is possible to make explicit how organisms come to be as organisms. To this end, I explore key onto- genetic events that help us clarify the core aspects of animal organisation and allow us to identify the developmental stage that marks the ontological transition between an organism in potency and an organism in actuality. The structure of this ontogenetic unfolding paral- lels the conceptual structure of the very notion of organism; the generation of the being of a particular organism parallels its definition. (shrink)

Neo-Kantianism emerged over the course of the 1860s and it occupied a leading position in the German universities from the 1870s until the First World War. Demands for getting "back to Kant" had become common since the early 1860s, and these demands were discussed in the meetings of the Philosophical Society of Berlin (Philosophische Gesellschaft zu Berlin; PGB), which was the international organization of Hegelians. In this paper I address some reactions among the PGB members to the 1860s Kant revival. (...) The journal "Der Gedanke", the organ of the PGB, reported closely how Kant returned to the spotlight of German philosophy. The reactions of the PGB members to the Kant revival was not only critical. Over the course of the 1860s the interest on Kant among the members grew little by little. (shrink)

Kant’s treatment of organic phenomena in the third _Critique_ is relatively well-known. Less known is that Schelling offered an original answer to the same problems in his early writings on the philosophy of nature. Even less known is the significance of his rethinking of the role of chemistry in his approach to organic phenomena. In this article, after outlining the problem of organic phenomena at the end of the eighteenth century, I reconstruct Schelling’s account of chemistry against the background of (...) Kant’s theory of matter. I show that, while Schelling endorses Kant’s verdict that chemistry is not a proper science, he nevertheless assigns to it a far greater scope and explanatory power than Kant does. After that, I briefly sketch Schelling’s solution to the problem of organic phenomena while stressing the significance of his thinking about chemistry for this solution. (shrink)

The theory of concepts advanced in the dissertation aims at accounting for a) how a concept makes successful practice possible, and b) how a scientific concept can be subject to rational change in the course of history. Traditional accounts in the philosophy of science have usually studied concepts in terms only of their reference; their concern is to establish a stability of reference in order to address the incommensurability problem. My discussion, in contrast, suggests that each scientific concept consists of (...) three components of content: 1) reference, 2) inferential role, and 3) the epistemic goal pursued with the concept's use. I argue that in the course of history a concept can change in any of these three components, and that change in one component—including change of reference—can be accounted for as being rational relative to other components, in particular a concept's epistemic goal.This semantic framework is applied to two cases from the history of biology: the homology concept as used in 19th and 20th century biology, and the gene concept as used in different parts of the 20th century. The homology case study argues that the advent of Darwinian evolutionary theory, despite introducing a new definition of homology, did not bring about a new homology concept (distinct from the pre-Darwinian concept) in the 19th century. Nowadays, however, distinct homology concepts are used in systematics/evolutionary biology, in evolutionary developmental biology, and in molecular biology. The emergence of these different homology concepts is explained as occurring in a rational fashion. The gene case study argues that conceptual progress occurred with the transition from the classical to the molecular gene concept, despite a change in reference. In the last two decades, change occurred internal to the molecular gene concept, so that nowadays this concept's usage and reference varies from context to context. I argue that this situation emerged rationally and that the current variation in usage and reference is conducive to biological practice.The dissertation uses ideas and methodological tools from the philosophy of mind and language, the philosophy of science, the history of science, and the psychology of concepts. (shrink)

In this article, I defend the idea that Kant’s interest in an emergent science in the 18th century as the Embriology (especially in the concept of epigenesis) allows to deepen in a soft naturalization of Kant’s trancendental idealism, as well as to justify the validity of a priori knowledge.