Switch to: References

Add citations

You must login to add citations.
  1. The Boundaries of Development.Lucie Laplane - 2011 - Biological Theory 6 (1):1-3.
    The tacit standard view that development ends once reproductive capacity is acquired (reproductive boundary, or ‘‘RB,’’ thesis) has recently been challenged by biologists and philosophers of biology arguing that development continues until death (death boundary, or ‘‘DB,’’ thesis). The relevance of these two theses is difficult to assess because the fact that there is no precise definition of development makes the determination of its temporal boundaries problematic. Taking into account this difficulty, this article tries to develop a new species-dependent perspective (...)
    Download  
     
    Export citation  
     
    Bookmark   12 citations  
  • The Boundaries of Development.Thomas Pradeu, Lucie Laplane, Michel Morange, Antonine Nicoglou & Michel Vervoort - 2011 - Biological Theory 6 (1):1 - 3.
    This special issue of Biological Theory is focused on development; it raises the problem of the temporal and spatial boundaries of development. From a temporal point of view, when does development start and stop? From a spatial point of view, what is it exactly that "develops", and is it possible to delineate clearly the developing entity? This issue explores the possible answers to these questions, and thus sheds light on the definition of development itself.
    Download  
     
    Export citation  
     
    Bookmark   9 citations  
  • Germ Cells are Made Semiotically Competent During Evolution.Franco Giorgi & Luis Emilio Bruni - 2016 - Biosemiotics 9 (1):31-49.
    Germ cells are cross-roads of development and evolution. They define the origin of every new generation and, at the same time, represent the biological end-product of any mature organism. Germ cells are endowed with the following capacities: to store a self-descriptive program, to accumulate a protein-synthesizing machinery, and to incorporate enough nourishment to sustain embryonic development. To accomplish this goal, germ cells do not simply unfold a pre-determined program or realize a sole instructive role. On the contrary, due to the (...)
    Download  
     
    Export citation  
     
    Bookmark  
  • Philosophy of Stem Cell Biology – an Introduction.Melinda Bonnie Fagan - 2013 - Philosophy Compass 8 (12):1147-1158.
    This review surveys three central issues in philosophy of stem cell biology: the nature of stem cells, stem cell experiments, and explanations of stem cell capacities. First, I argue that the fundamental question ‘what is a stem cell?’ has no single substantive answer. Instead, the core idea is explicated via an abstract model, which accounts for many features of stem cell experiments. The second part of this essay examines several of these features: uncertainty, model organisms, and manipulability. The results shed (...)
    Download  
     
    Export citation  
     
    Bookmark   7 citations  
  • Social experiments in stem cell biology.Melinda B. Fagan - 2011 - Perspectives on Science 19 (3):235-262.
    Stem cell biology is driven by experiment. Its major achievements are striking experimental productions: "immortal" human cell lines from spare embryos (Thomson et al. 1998); embryo-like cells from "reprogrammed" adult skin cells (Takahashi and Yamanaka 2006); muscle, blood and nerve tissue generated from stem cells in culture (Lanza et al. 2009, and references therein). Well-confirmed theories are not so prominent, though stem cell biologists do propose and test hypotheses at a profligate rate. 1 This paper aims to characterize the role (...)
    Download  
     
    Export citation  
     
    Bookmark   3 citations  
  • Crucial Stem Cell Experiments? Stem Cells, Uncertainty, and Single-Cell Experiments.Melinda Bonnie Fagan - 2015 - Theoria: Revista de Teoría, Historia y Fundamentos de la Ciencia 30 (2):183-205.
    I have previously argued that stem cell experiments cannot demonstrate that a single cell is a stem cell (Fagan 2013a, b). Laplane and others dispute this claim, citing experiments that identify stem cells at the singlecell level. This paper rebuts the counterexample, arguing that the alleged ‘crucial stem cell experiments’ do not measure self-renewal for a single cell, do not establish a single cell’s differentiation potential, and, if interpreted as providing results about single cells, fall into epistemic circularity. I then (...)
    Download  
     
    Export citation  
     
    Bookmark   1 citation  
  • Explanation in Biology: An Enquiry into the Diversity of Explanatory Patterns in the Life Sciences.P.-A. Braillard and C. Malaterre (ed.) - 2015 - Springer.
    Download  
     
    Export citation  
     
    Bookmark   2 citations