7 found
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  1. What is an Organism? An Immunological Answer.Thomas Pradeu - 2010 - History and Philosophy of the Life Sciences 32 (2-3):247-267.
    The question “What is an organism?”, formerly considered as essential in biology, has now been increasingly replaced by a larger question, “What is a biological individual?”. On the grounds that i) individuation is theory-dependent, and ii) physiology does not offer a theory, biologists and philosophers of biology have claimed that it is the theory of evolution by natural selection which tells us what counts as a biological individual. Here I show that one physiological field, immunology, offers a theory, which makes (...)
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  2. Galatea of the Microbes.Thomas Pradeu - 2014 - The Philosophers' Magazine 67:89-95.
    This paper shows that the identity of living things is a composite reality. It also suggests that the immune system constitutes a unifying process for the organism.
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    Understanding Multicellularity: The Functional Organization of the Intercellular Space.Leonardo Bich, Thomas Pradeu & Jean-Francois Moreau - 2019 - Frontiers in Physiology 10.
    The aim of this paper is to provide a theoretical framework to understand how multicellular systems realize functionally integrated physiological entities by organizing their intercellular space. From a perspective centered on physiology and integration, biological systems are often characterized as organized in such a way that they realize metabolic self-production and self-maintenance. The existence and activity of their components rely on the network they realize and on the continuous management of the exchange of matter and energy with their environment. One (...)
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  4. Ontologies of Living Beings: Introduction.Adam Ferner & Thomas Pradeu - 2017 - Philosophy, Theory, and Practice in Biology 9 (4).
    Part of a special issue, Ontologies of Living Beings, guest-edited by A. M. Ferner and Thomas Pradeu.
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    Protective Microbiota: From Localized to Long-Reaching Co-Immunity.Lynn Chiu, Thomas Bazin, Marie-Elise Truchetet, Thierry Schaeverbeke, Laurence Delhaes & Thomas Pradeu - 2017 - Frontiers Immunology 8:1678.
    Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance localized within a microenvironment. This review shows that the protection against pathogens also involves the mitigation of pathogenic impact without eliminating the pathogens (i.e., “disease tolerance”) and the containment of microorganisms to prevent pathogenic spread. Protective microorganisms can have an impact beyond their niche, interfering with (...)
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  6. Toolbox Murders: Putting Genes in Their Epigenetic and Ecological Contexts: P. Griffiths and K. Stotz: Genetics and Philosophy: An Introduction. [REVIEW]Thomas Pradeu - 2016 - Biology and Philosophy 31 (1):125-142.
    Griffiths and Stotz’s Genetics and Philosophy: An Introduction offers a very good overview of scientific and philosophical issues raised by present-day genetics. Examining, in particular, the questions of how a “gene” should be defined and what a gene does from a causal point of view, the authors explore the different domains of the life sciences in which genetics has come to play a decisive role, from Mendelian genetics to molecular genetics, behavioural genetics, and evolution. In this review, I highlight what (...)
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    Immune-Mediated Repair: A Matter of Repair.Paôline Laurent, Marie-Elise Truchetet, Valérie Jolivel, Pauline Manicki, Lynn Chiu & Thomas Pradeu - 2017 - Frontiers in Immunology 8:454.
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