This paper outlines some of the new epistemological and ontological assumptions of contemporary technoscience thereby reframing the question of an epochal break. Important aspects are the question of a new techno-rationality, but also the constitution of a ‘New World Order Inc.’, with its new ‘politics of life itself’, the reconfiguration of categories such as race, class and gender in technoscience, as well as the amalgamation of everyday life, technoscience and culture. Given the difficulties of ‘proving’ a new episteme (or even (...) epoch), I change perspective by reflecting on the epistemological vantage point from which the interpretation of technoscience as a new episteme or epoch becomes (im)plausible—confronting traditional approaches of philosophy and history of science and technology assessment (TA) with interventional approaches, such as postcolonial and feminist cultural studies of technoscience. (shrink)