This paper introduces Holistic Free Will (HFW), a transformative framework that reconceptualizes autonomy as a dynamic, relational, and ethically aspirational process embedded within structured realities. Distinct from traditional theories like libertarian free will and compatibilism, HFW integrates interdisciplinary insights from neuroscience, moral philosophy, and cultural traditions to provide a comprehensive understanding of free will that aligns individual agency with systemic and relational contexts. HFW emphasizes structured reality as comprising four dimensions—natural laws, human constructs, social norms, and personal histories—that act not (...) as constraints but as enablers of ethical autonomy and moral development. Central to the framework are mechanisms such as reflective veto, self-reflection, and virtue cultivation, which empower individuals to navigate deterministic influences and align actions with enduring ethical principles like justice, empathy, and humility. HFW’s practical applications across governance, education, and social systems, demonstrating its capacity to address global challenges such as social justice, environmental sustainability, and relational harmony. Case studies illustrate how structured realities foster personal and collective growth, positioning HFW as a tool for bridging theoretical insights and actionable strategies. By advancing autonomy as a relational and developmental process, HFW offers a groundbreaking model for ethical agency and societal transformation. (shrink)