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The strategy of biological research programmes: Reassessing the ‘dark age’ of biochemistry, 1910–1930

Annals of Science 47 (2):139-150 (1990)

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The controversy between John H. Northrop and Max Delbrück on the formation of bacteriophage: Bacterial synthesis or autonomous multiplication?Ton van Helvoort - 1992 - Annals of Science 49 (6):545-575.details SummaryIn the 1940s a controversy developed between John H. Northrop (Nobel Laureate, 1946) and Max Delbrück (Nobel Laureate, 1969) on the formation of bacteriophage. From the historiography of molecular biology there emerges a picture of an obstinate Northrop who repudiated the ‘correct’ insights revealed by the experiments of Delbrück. The established reputation of Northrop confronts one with the question of why Delbrück's epoch-making experiments were not convincing for Northrop. It will be argued that this was a consequence of local incommensurability (...) Download Export citation Bookmark 8 citations
(1 other version)The discovery of oxidative phosphorylation: a conceptual off-shoot from the study of glycolysis.John N. Prebble - 2010 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 41 (3):253-262.details The origins of oxidative phosphorylation, initially known as aerobic phosphorylation, grew out of three research areas of muscle metabolism, creatine phosphorylation, aerobic metabolism of lactic acid in muscle, and studies on the nature and role of adenosine triphosphate . Much of this work centred round the laboratory of Otto Meyerhof, and most of those contributing to the study of aerobic phosphorylation were influenced by that laboratory: particularly Lipmann and also Ochoa. The work of Engelhardt on ATP levels in blood also (...) Download Export citation Bookmark 4 citations
Conference report “Stoffwechsel. Histories of metabolism”, workshop organized by Mathias Grote at Technische Universität Berlin, November 28–29th, 2014. [REVIEW]Mathias Grote & Lara Keuck - 2015 - History and Philosophy of the Life Sciences 37 (2):210-218.details Historical analyses of what metabolism has been conceived of, how concepts of metabolism were related to disciplines such as nineteenth-century nutritional physiology or twentieth-century biochemistry, and how their genealogies relate to the current developments may be helpful to understand the various, at times polemic, ways in which the boundaries between metabolism and heredity have been re-drawn. Against this background, a small number of scholars gathered in Berlin for a workshop that equally aimed at bringing new stories to the fore, and (...) Download Export citation Bookmark
(1 other version)The discovery of oxidative phosphorylation: a conceptual off-shoot from the study of glycolysis.John N. Prebble - 2010 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 41 (3):253-262.details Download Export citation Bookmark 3 citations

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