Our aim in the present paper is to approach the nature of life from the perspective of autonomy, showing that this perspective can be helpful for overcoming the traditional Cartesian gap between the physical and cognitive domains. We first argue that, although the phenomenon of life manifests itself as highly complex and multidimensional, requiring various levels of description, individual organisms constitute the core of this multifarious phenomenology. Thereafter, our discussion focuses on the nature of the organization of individual living entities, (...) proposing autonomy as the main concept to grasp it. In the second part of the article we show how autonomy is also fundamental to explaining major evolutionary transitions, in an attempt to rethink evolution from the point of view of the organizational structure of the entities/organisms involved. This gives further support to the idea of autonomy not only as a key to understanding life in general but also the complex expressions of it that we observe on our planet. Finally, we suggest a possible general principle that underlies those evolutionary transitions, which allow for the open-ended redefinition of autonomous systems: namely, the relative dynamic decoupling that must be articulated among distinct parts, modules or modes of operation in these systems. (shrink)

Analysis of two key ways of characterizing genes—as causes of phenotypic effects and as genomic DNA sequences—has yielded widespread pessimism that they can be united in a coherent gene concept. This raises important questions about the epistemology of genomic research: If analysis of a genome sequence cannot yield information about genes defined both in terms of their products and their DNA sequence, then what could we learn from it? I investigate basic tools of genomic analysis, argue that they do not (...) reflect the application of either gene concept, and clarify how we learn from genomic research. (shrink)

From a subjective point of view, we take the existence of integrated entities, i.e., ourselves as the most unproblematic given, and blithely project such integrity onto untold many “entities” far and wide. However, from a naturalistic perspective, accounting for anything more integral than the attachments and attractions that are explicable in terms of the four fundamental forces of physics has been anything but straightforward. If we take it that the universe begins as an integral unity and explodes into progressive stages (...) of internal detachment, then we can also fathom the idea that eddies of relative detachment becoming increasingly integral. Helmuth Plessner made a powerful case for the onset of “positionality” constituting one of the major transitions in nature. Surely, the emergence of “entities” that position themselves in relation to their surround marks a decisive transition in relative levels of detachment and some would say “autonomy.” It would follow, with no less force, that where and when entities can be seen to be normatively integrated, and indeed to be the agents of their own normativity, that another threshold of detachment has been crossed. The paper introduces and explores the idea that normativity, embedded in a wide-ranging theory of natural detachment, can be considered an emergent force of nature that is requisite to accounting for levels of integration beyond that which is explicable in terms of the four fundamental forces of physics. Following this line of enquiry, we argue that the first expression of a fully, normatively-integrated life-form is neither a spoken language user nor for that matter an individual but rather the neoteny-based, Homo erectus Group. In so doing we claim to have made an inroad into embedding the force of normativity into a wide-ranging naturalist framework, to have provided philosophical anthropology with a new point of departure, and at least playfully, to have given some naturalistic grist to Hegel’s proclamation that spirit is the truth of nature. (shrink)

Axel Honneth and Hans Joas claim that Helmuth Plessner’s philosophical anthropology is problematically ‘solipsistic’ insofar as it fails to appreciate the ways in which human persons or selves are brought into being and given their characteristic powers of reflection and action by social processes. Here I review the main argument of Plessner’s Die Stufen des Organischen und der Mensch: Einleitung in die philosophische Anthropologie with this criticism in mind, giving special attention to Plessner’s accounts of organic being, personhood, language, sociality, (...) and historicity in that text. I argue that Honneth and Joas’s criticisms understate the extent to which Plessner takes sociality to be a constitutive condition of human forms of life within the structure he calls ‘ex-centric positionality’. This reading of Plessner also provides resources for answering a more common criticism of his philosophical anthropology – namely, that it is problematically ‘essentialist’, paying insufficient heed t.. (shrink)

The paper examines some of the significant new developments in the epistemological framing of systems theory, and their application within the information and management sciences. Specifically, the article argues that Information Systems – at its heart a systems-science – requires an ongoing discourse into how the metaphors of ‘living systems’, ‘complex systems’, and ‘complexity’ apply to the theoretical foundations of the IS discipline at large. Pragmatically, the implications of developing a complex and living systems framework to investigate IS phenomena has (...) the capacity to synthesise the very way information systems researchers consider their discipline, and the scientific inquiry of it. The “information system” becomes a decentralised, complex and evolving entity, where notions of chaos theory; system self-organisation; autopoietic and dissipative networks; emergence; entropy; and nonlinear dynamics; provide a rich and novel way to investigate system behaviours, human cognitive behaviours, and the management and business contexts in which those behaviours occur. (shrink)

The paper describes the change from molecular genetics to postgenomic biology. It focuses on phenomena in the regulation of gene expression that provide a break with the central dogma, according to which sequence specificity for a gene product must be template derived. In its place we find what is called here ‘constitutive molecular epigenesis’. Its three classes of phenomena, which I call sequence ‘activation’, ‘selection’ and ‘creation’, are exemplified by processes such as transcriptional activation, alternative cis- and trans-splicing, and RNA (...) editing. These phenomena support the following main theses of the paper: 1. Other molecular resources share the causal role of ‘genes’: the ‘causal specificity’ for the linear sequence of any gene product is distributed between the coding sequence, cis-acting sequences, trans-acting factors, environmental signals, and the contingent history of the cell (the cellular code) (thesis of distributed causal specificity). 2. These multiple and overlapping processing and targeting mechanisms amplify the repertoire of RNA and protein products specified through the eukaryotic genome, expanding the possibilities specified by the literal code of DNA (thesis of genetic underdeterminism). 3. These mechanisms of gene expression change the focus of postgenomic research from single molecules and their molecular, biochemical and intrinsic function to their cellular, constituent, component or contextual function due to their recruitment and organization in complex cellular networks. In other words, all agents involved in the regulation of gene expression, including DNA, must interact with other agents to achieve full specificity, which is imposed by regulated recruitment and combinatorial control (theses of regulated recruitment and of system analysis). I conclude from these three main theses that the complexity of higher organisms lies not in its number of genes but in the flexibility, versatility and reactivity of its whole genome. (shrink)