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2001 and all that: A tale of a third science

Karola Stotz

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Genomic Programs as Mechanism Schemas: A Non-Reductionist Interpretation.Tudor M. Baetu - 2012 - British Journal for the Philosophy of Science 63 (3):649-671.details In this article, I argue that genomic programs are not substitutes for multi-causal molecular mechanistic explanations of inheritance, but abstract representations of the same sort as mechanism schemas already described in the philosophical literature. On this account, the program analogy is not reductionistic and does not ignore or underestimate the active contribution of epigenetic elements to phenotypes and development. Rather, genomic program representations specifically highlight the genomic determinants of inheritance and their organizational features at work in the wider context of (...) Download Export citation Bookmark 4 citations
A Defense of Syntax-Based Gene Concepts in Postgenomics: Genes as Modular Subroutines in the Master Genomic Program.Tudor M. Baetu - 2011 - Philosophy of Science 78 (5):712-723.details The purpose of this article is to update and defend syntax-based gene concepts. I show how syntax-based concepts can and have been extended to accommodate complex cases of processing and gene expression regulation. In response to difficult cases and causal parity objections, I argue that a syntax-based approach fleshes out a deflationary concept defining genes as genomic sequences and organizational features of the genome contributing to a phenotype. These organizational features are an important part of accepted molecular explanations, provide the (...) Download Export citation Bookmark 2 citations
When Traditional Essentialism Fails: Biological Natural Kinds.Robert A. Wilson, Matthew J. Barker & Ingo Brigandt - 2007 - Philosophical Topics 35 (1-2):189-215.details Essentialism is widely regarded as a mistaken view of biological kinds, such as species. After recounting why (sections 2-3), we provide a brief survey of the chief responses to the “death of essentialism” in the philosophy of biology (section 4). We then develop one of these responses, the claim that biological kinds are homeostatic property clusters (sections 5-6) illustrating this view with several novel examples (section 7). Although this view was first expressed 20 years ago, and has received recent discussion (...) Download Export citation Bookmark 109 citations
Molecular Epigenesis: Distributed Specificity as a Break in the Central Dogma.Karola Stotz - 2006 - History and Philosophy of the Life Sciences 28 (4):533 - 548.details The paper argues against the central dogma and its interpretation by C. Kenneth Waters and Alex Rosenberg. I argue that certain phenomena in the regulation of gene expression provide a break with the central dogma, according to which sequence specificity for a gene product must be template derived. My thesis of 'molecular epigenesis' with its three classes of phenomena, sequence 'activation', 'selection', and 'creation', is exemplified by processes such as transcriptional activation, alternative cis- and trans-splicing, and RNA editing. It argues (...) Download Export citation Bookmark 43 citations

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