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Adaptive evolution of highly mutable loci in pathogenic bacteria

E. Richard Moxon, Richard E. Lenski & Paul B. Rainey

Perspectives in Biology and Medicine 42 (1):154-155 (1997)

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Bridges between development and evolution.Eva Jablonka & Marion J. Lamb - 1998 - Biology and Philosophy 13 (1):119-124.details Adaptive evolution is usually assumed to be directed by selective processes, development by instructive processes; evolution involves random genetic changes, development involves induced epigenetic changes. However, these distinctions are no longer unequivocal. Selection of genetic changes is a normal part of development in some organisms, and through the epigenetic system external factors can induce selectable heritable variations. Incorporating the effects of instructive processes into evolutionary thinking alters ideas about the way environmental changes lead to evolutionary change, and about the interplay (...) Download Export citation Bookmark 2 citations
A powerful toolkit for synthetic biology: Over 3.8 billion years of evolution.Lynn J. Rothschild - 2010 - Bioessays 32 (4):304-313.details The combination of evolutionary with engineering principles will enhance synthetic biology. Conversely, synthetic biology has the potential to enrich evolutionary biology by explaining why some adaptive space is empty, on Earth or elsewhere. Synthetic biology, the design and construction of artificial biological systems, substitutes bio‐engineering for evolution, which is seen as an obstacle. But because evolution has produced the complexity and diversity of life, it provides a proven toolkit of genetic materials and principles available to synthetic biology. Evolution operates on (...) Download Export citation Bookmark
Evolutionary Chance Mutation: A Defense of the Modern Synthesis' Consensus View.Francesca Merlin - 2010 - Philosophy, Theory, and Practice in Biology 2 (20130604).details One central tenet of the Modern Evolutionary Synthesis , and the consensus view among biologists until now, is that all genetic mutations occur by “chance” or at “random” with respect to adaptation. However, the discovery of some molecular mechanisms enhancing mutation rate in response to environmental conditions has given rise to discussions among biologists, historians and philosophers of biology about the “chance” vs “directed” character of mutations . In fact, some argue that mutations due to a particular kind of mutator (...) Download Export citation Bookmark 19 citations
The evolution of mutation rates: separating causes from consequences.Paul D. Sniegowski, Philip J. Gerrish, Toby Johnson & Aaron Shaver - 2000 - Bioessays 22 (12):1057-1066.details Download Export citation Bookmark 13 citations
Non‐random mutation: The evolution of targeted hypermutation and hypomutation.Iñigo Martincorena & Nicholas M. Luscombe - 2013 - Bioessays 35 (2):123-130.details A widely accepted tenet of evolutionary biology is that spontaneous mutations occur randomly with regard to their fitness effect. However, since the mutation rate varies along a genome and this variation can be subject to selection, organisms might evolve lower mutation rates at loci where mutations are most deleterious or increased rates where mutations are most needed. In fact, mechanisms of targeted hypermutation are known in organisms ranging from bacteria to humans. Here we review the main forces driving the evolution (...) Download Export citation Bookmark 6 citations

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