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Waddington’s epigenetics or the pictorial meetings of development and genetics

Antonine Nicoglou

History and Philosophy of the Life Sciences 40 (4):61 (2018)

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Épigénétique : les écueils d’une transposition du biologique au social.Guillaume Pelletier - 2019 - Dialogue 58 (1):1-26.details This article offers an overview of the risks related to some representations of epigenetics in the process of making social and medical recommendations. After exploring different representations of epigenetics in popular literature and media discourses, I identify some of the premature conclusions that could emerge from such discourses, stressing issues related to parental responsibility—especially as they relate to women—regarding the transmission of epigenetic marks. I then propose some epistemological considerations regarding developmental biology in order to draw a more nuanced picture (...) Download Export citation Bookmark
Introduction: sketches of a conceptual history of epigenesis.Antonine Nicoglou & Charles T. Wolfe - 2018 - History and Philosophy of the Life Sciences 40 (4):64.details This is an introduction to a collection of articles on the conceptual history of epigenesis, from Aristotle to Harvey, Cavendish, Kant and Erasmus Darwin, moving into nineteenth-century biology with Wolff, Blumenbach and His, and onto the twentieth century and current issues, with Waddington and epigenetics. The purpose of the topical collection is to emphasize how epigenesis marks the point of intersection of a theory of biological development and a theory of active matter. We also wish to show that the concept (...) Download Export citation Bookmark 3 citations
The environment: An ambiguous concept in Waddington's biology.Laurent Loison - 2022 - Studies in History and Philosophy of Science Part A 91 (C):181-190.details Download Export citation Bookmark 1 citation
Homeorhesis: envisaging the logic of life trajectories in molecular research on trauma and its effects.Stephanie Lloyd, Alexandre Larivée & Pierre-Eric Lutz - 2022 - History and Philosophy of the Life Sciences 44 (4):1-29.details What sets someone on a life trajectory? This question is at the heart of studies of 21st-century neurosciences that build on scientific models developed over the last 150 years that attempt to link psychopathology risk and human development. Historically, this research has documented persistent effects of singular, negative life experiences on people’s subsequent development. More recently, studies have documented neuromolecular effects of early life adversity on life trajectories, resulting in models that frame lives as disproportionately affected by early negative experiences. (...) Download Export citation Bookmark 1 citation
Can you remember silence? Epigenetic memory and reversibility as a site of intervention.Stephanie Lloyd, Pierre-Eric Lutz & Chani Bonventre - 2023 - Bioessays 45 (7):2300019.details Just over 20 years ago, molecular biologists Leonie Ringrose and Renato Paro published an article with a provocative title, “Remembering Silence”, in BioEssays. The article focused on how epigenetic elements could return to their silent state, operationally defined as their epigenetic status before their modulation by experimental or environmental factors. Though Ringrose and Paro's article was on fruit flies and factors affecting embryological growth, the article asked a question of considerable importance to rapidly expanding research in neuroepigenetics on the correlation (...) Download Export citation Bookmark

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