In 1919 the Animal Breeding Research Department was established in Edinburgh. This Department, later renamed the Institute of Animal Genetics, forged an international reputation, eventually becoming the centrepiece of a cluster of new genetics research units and institutions in Edinburgh after the Second World War. Yet despite its significance for institutionalising animal genetics research in the UK, the origins and development of the Department have not received as much scholarly attention as its importance warrants. This paper sheds new light on (...) Edinburgh’s place in early British genetics by drawing upon recently catalogued archival sources including the papers of James Cossar Ewart, Regius Professor of Natural History at the University of Edinburgh between 1882 and 1927. Although presently a marginal figure in genetics historiography, Ewart established two sites for experimental animal breeding work between 1895 and 1911 and played a central role in the founding of Britain’s first genetics lectureship, also in 1911. These early efforts helped to secure government funding in 1913. However, a combination of the First World War, bureaucratic problems and Ewart’s personal ambitions delayed the creation of the Department and the appointment of its director by another six years. This paper charts the institutionalisation of animal breeding and genetics research in Edinburgh within the wider contexts of British genetics and agriculture in the early twentieth century. (shrink)

This article uses the case of pregnancy testing in Britain to investigate the process whereby new and often controversial reproductive technologies are made visible and normalized in mainstream entertainment media. It shows how in the 1980s and 1990s the then nascent product placement industry was instrumental in embedding pregnancy testing in British cinema and television's dramatic productions. In this period, the pregnancy-test close-up became a conventional trope and the thin blue lines associated with Unilever's Clearblue rose to prominence in mainstream (...) consumer culture. This article investigates the aestheticization of pregnancy testing and shows how increasingly visible public concerns about ‘schoolgirl mums’, abortion and the biological clock, dramatized on the big and small screen, propelled the commercial rise of Clearblue. It argues that the Clearblue close-up ambiguously concealed as much as it revealed; abstraction, ambiguity and flexibility were its keys to success. (shrink)

Today, many pregnancy guides mention a nesting instinct. According to this, pregnant women would be seized by an urge to create the right environment for their child, for example to buy baby equipment or clean the apartment. The concept of the nesting instinct forms a specific configuration of knowledge: While it is widespread in the popular field, it occupies a marginal position in the scientific field. In this paper, I will investigate the historical epistemology of this form of knowledge. In (...) so doing, the following questions are addressed: How did the knowledge about a nesting instinct during pregnancy form? How was the nest as a specific natural-anthropogenic environment constructed? And to what extent do notions of gender and environment interact here? To answer these questions, the study takes the perspective of a history of knowledge in transit, in the longue durée from the nineteenth century to the present. The investigation reveals a gradual feminization of the concept of environment in the knowledge of the nesting instinct. Whereas in the nineteenth century it was often considered a male behavioral pattern and the nest was an analogy to the house, in the first decades of the twentieth century, the instinct transformed into a primarily female characteristic, with the nest representing the interior of the home. A decisive condition for this circulation of knowledge was that the nest became a ‘metaphorical thing’. As such, the nest did not simply lead to naturalization, but denoted a natural-social in-between space that increasingly became the goal of female care work. (shrink)

ZusammenfassungIn heutigen Schwangerschaftsratgebern ist oft von einem Nestbauinstinkt zu lesen. Demnach würden Schwangere von einem Trieb ergriffen, die passende Umwelt für ihr Kind zu gestalten, also Babyausstattung zu kaufen oder die Wohnung zu putzen. Dabei bildet das Konzept des Nestbauinstinkts eine spezifische Wissenskonfiguration: Während es im populären Bereich verbreitet ist, nimmt es im wissenschaftlichen Bereich eine marginale Position ein. Im vorliegenden Beitrag soll der historischen Epistemologie dieser Wissensform nachgegangen werden. Im Vordergrund stehen folgende Fragen: Wie formierte sich das Wissen um (...) einen Nestbauinstinkt in der Schwangerschaft? Auf welche Weise wurde das Nest als spezifische natural-anthropogene Umwelt hergestellt? Und inwiefern interagieren hier Vorstellungen von Geschlecht und Umwelt? Dazu nimmt die wissensgeschichtliche Analyse die Perspektive einer longue durée vom 19. Jahrhundert bis heute ein. Die Untersuchung ergibt eine graduelle Feminisierung des Umweltkonzepts im Wissen des Nestbauinstinkts. Während er im 19. Jahrhundert oft als männliches Verhaltensmuster galt und das Nest ein Analogon zum Wohnhaus bildete, transformierte sich der Instinkt in den ersten Jahrzehnten des 20. Jahrhunderts zu einer primär weiblichen Eigenschaft, bei der das Nest für den Innenraum des Zuhauses stand. Dabei zirkulierte das Wissen zwischen verschiedenen Bereichen, wofür eine maßgebliche Bedingung war, dass sich das Nest zum ‚metaphorischen Ding‘ wandelte. Als solches führte das Nest nicht einfach zu einer Naturalisierung, sondern bezeichnete einen familiären natural-sozialen Zwischenraum, der zunehmend zum Ziel weiblich konnotierter Sorge-Arbeit wurde. (shrink)

In the mid-twentieth century film studios sent their screenplays to Hollywood's official censorship body, the Production Code Administration, and to the Catholic Church's Legion of Decency for approval and recommendations for revision. This article examines the negotiations between filmmakers and censorship groups in order to show the stories that censors did, and did not, want told about pregnancy, childbirth and abortion, as well as how studios fought to tell their own stories about human reproduction. I find that censors considered pregnancy (...) to be a state of grace and a holy obligation that was restricted to married women. For censors, human reproduction was not only a private matter, it was also an unpleasant biological process whose entertainment value was questionable. They worried that realistic portrayals of pregnancy and childbirth would scare young women away from pursuing motherhood. In addition, I demonstrate how filmmakers overcame censors’ strict prohibitions against abortion by utilizing ambiguity in their storytelling. Ultimately, I argue that censors believed that pregnancy and childbirth should be celebrated but not seen. But if pregnancy and childbirth were required then censors preferred mythic versions of motherhood instead of what they believed to be the sacred but horrific biological reality of human reproduction. (shrink)

Patient-derived xenografts are currently promoted as new translational models in precision oncology. PDXs are immunodeficient mice with human tumors that are used as surrogate models to represent specific types of cancer. By accounting for the genetic heterogeneity of cancer tumors, PDXs are hoped to provide more clinically relevant results in preclinical research. Further, in the function of so-called “mouse avatars”, PDXs are hoped to allow for patient-specific drug testing in real-time. This paper examines the circulation of knowledge and bodily material (...) across the species boundary of human and personalized mouse model, historically as well as in contemporary practices. PDXs raise interesting questions about the relation between animal model and human patient, and about the capacity of hybrid or interspecies models to close existing translational gaps. We highlight that the translational potential of PDXs not only depends on representational matching of model and target, but also on temporal alignment between model development and practical uses. Aside from the importance of ensuring temporal stability of human tumors in a murine body, the mouse avatar concept rests on the possibility of aligning the temporal horizons of the clinic and the lab. We examine strategies to address temporal challenges, including cryopreservation and biobanking, as well as attempts to speed up translation through modification and use of faster developing organisms. We discuss how featured model virtues change with precision oncology, and contend that temporality is a model feature that deserves more philosophical attention. (shrink)

The ways in which other animal species can be informative about human biology are not exhausted by the traditional picture of the animal model. In this paper, I propose to distinguish two roles which laboratory organisms can have in biomedical research. In the more traditional case, organisms act as surrogates for human beings, and as such are expected to be more manageable replicas of humans. However, animal models can inform us about human biology in a much less straightforward way, by (...) being used as measuring devices—what I call their instrumental role. I first characterize this role and provide criteria for it, before illustrating it with some examples from biomedical research, especially cancer research. In such an instrumental role, phenotypes are not expected to phenocopy human phenomena, but instead have the purely instrumental value of detecting or measuring differences. I argue that the instrumental role is more prevalent than might first be suspected, and that some characteristics of contemporary biomedical research are increasingly shifting the use of laboratory organisms to the instrumental role. Finally, in light of the distinction proposed, I discuss the meaning of the expression “animal model”. (shrink)