The purpose of this study was to use drama as a springboard for promoting argumentation among 91 first-semester undergraduate medical students in Colombia during a complete teaching–learning sequence supervised by the same teacher. The drama used was the play Should’ve, written by Nobel laureate Roald Hoffmann. The data was derived from students’ written responses, audio and video recordings, and written field notes. This investigation provides evidence that an approach combining drama and argumentation could increase students’ awareness of the relevance of (...) ethics in science as one of the features of science. The findings show that the play Should’ve can be useful for promoting students’ argumentation and is also appropriate for medical students. Future studies could include other science disciplines ; students of other ages; and other plays and experiments in other parts of the world. (shrink)