The development of gene-editing technologies, such as the clustered regularly interspaced short palindromic repeats and associated Cas9 endonuclease system, coincides with a rapidly expanding knowledge of the role of genes in the human ageing process. This raises the prospect that, in addition to the treatment of genetic diseases and disorders, it may become possible to use gene-editing technologies to alter the ageing process and significantly extend the maximum human lifespan. Germline editing poses distinctive problems due to its implications for individual (...) members of future, unborn generations. In this essay, I wish to home in, narrowly, on a single ethical objection to extending the lifespan of future generations by editing the human germline. The objection suggests that to extend lifespans is to unethically inflict the harm of loneliness on future people. I claim that the argument rests on assumptions that ought to be rejected. (shrink)

In a 2003 Science article, Eric Juengst and colleagues asserted, “NIH [National Institutes of Health] has a responsibility to help society respond to the implications of antiaging research for whic...

Various debates on the desirability and rationality of life-extending enhancements have been pursued under the presupposition that a generic psychological theory of personal identity is correct. I here discuss how the narrative approach to personal identity can contribute to these debates. In particular, I argue that two versions of the narrative approach offer good reasons to reject an argument against the rationality of life-extending enhancements.

One of the strongest objections to the development and use of substantially life-extending interventions is that they would exacerbate existing unjust disparities of healthy lifespans between rich and poor members of society. In both popular opinion and ethical theory, this consequence is sometimes thought to justify a ban on life-prolonging technologies. However, the practical and ethical drawbacks of banning receive little attention, and the viability of alternative policies is seldom considered. Moreover, where ethicists do propose alternatives, there is scant effort (...) to consider their merits in light of developing world priorities. In response to these shortcomings, I distinguish four policy options and, on the basis of a plausible intuition about fairness, evaluate their implications for a fair distribution of healthy lifespans. I claim that even in developing nations it would be fairest to favor policies that promote equal access to at least one promising category of substantially life-extending intervention: calorie restriction mimetics. (shrink)

Abstract Objections to life extension often focus on its effects for individual well-being. Prominent amongst these concerns is the possibility that life extending technologies will extend lifespan without preventing the ageing of the mind. Writers on the subject express the fear that life extending drugs will keep us physically youthful whilst our minds decay, succumbing to dementia, boredom, and loneliness. Generally these fears remain speculative, in part due to the absence of genuine life extending technologies. In this paper, however, I (...) examine the implications of an existing life extension technology. Caloric restriction (CR) and drugs that mimic its effects, such as rapamycin, metformin and resveratrol have been shown to increase average and maximum lifespan in a wide variety of organisms, and seem likely to do so in humans. Moreover, some CR mimetic drugs (CRMs) are already widely used. This means that they present a pressing test case for fears about mental ageing in an extended life. Misgivings about mental ageing can be divided into biomedical factors such as the likelihood of brain ageing, and psychological factors such as loss of meaning and boredom. I argue that studies of CR suggest that brain ageing will be beneficially slowed. However, it is less clear that deleterious aspects of psychological ageing can be similarly retarded. I argue that this reduces the desirability of life extension unless major social changes can be made. (shrink)

Debates about the ethical and social implications of research that aims to extend human longevity by intervening in the ageing process have paid little attention to the attitudes of members of the general public. In the absence of empirical evidence, conflicting assumptions have been made about likely public attitudes towards life-extension. In light of recent calls for greater public involvement in such discussions, this target article presents findings from focus groups and individual interviews which investigated whether members of the general (...) public identify ethical issues surrounding life-extension, and if so, what these ethical issues are? In this study, while some participants were concerned primarily with the likely personal consequences of life-extension, for others the question of whether or not to pursue interventions to extend longevity, and how they should be implemented, clearly raised important ethical issues, many of which have been prominent in debates among bioethicists. (shrink)