Climate change prevention necessitates the communication of transparent and reliable scientific evidence to improve public awareness and support. Felt responsibility is an essential factor influencing human environment-related psychology and behavior. However, the knowledge about the relationship between the felt responsibility and perceived uncertainty of scientific evidence regarding climate change has remained limited. The current study examines factors associated with the perceived uncertainty of scientific evidence (including felt responsibility to act on climate change) among stakeholders of marine and coastal ecosystems in (...) 42 countries. Employing the Bayesian Mindsponge Framework (BMF) analytics on a dataset of 709 stakeholders generated by MaCoBioS—a research project funded by the European Commission Horizon 2020, we reveal several main insights. Stakeholders with lower educational levels, being males and not from high-income countries, are more likely to think scientific evidence regarding how to act on climate change is uncertain. Moreover, people with a higher felt responsibility to act on climate change are also more likely to perceive higher uncertainty of scientific evidence. Based on these findings, we discuss how scientific evidence should be communicated to build the eco-surplus culture and, subsequently, the felt responsibility of stakeholders while inoculating them from climate change misinformation and disinformation. (shrink)