Phylogenetic models traditionally represent the history of life as having a strictly-branching tree structure. However, it is becoming increasingly clear that the history of life is often not strictly-branching; lateral gene transfer, endosymbiosis, and hybridization, for example, can all produce lateral branching events. There is thus motivation to allow phylogenetic models to have a reticulate structure. One proposal involves the reconciliation of genealogical discordance. Briefly, this method uses patterns of disagreement – discordance – between trees of different genes to add (...) lateral branching events to phylogenetic trees of taxa, and to estimate the most likely cause of these events. I use this practice to argue for: (1) a need for expanded accounts of multiple-models idealization, (2) a distinction between automatic and manual de-idealization, and (3) recognition that idealization may serve the meso-level aims of science in a different way than hitherto acknowledged. (shrink)

Hájek (Erkenntnis 70(2):211–235, 2009) argues that probabilities cannot be the limits of relative frequencies in counterfactual infinite sequences. I argue for a different understanding of these limits, drawing on Norton’s (Philos Sci 79(2):207–232, 2012) distinction between approximations (inexact descriptions of a target) and idealizations (separate models that bear analogies to the target). Then, I adapt Hájek’s arguments to this new context. These arguments provide excellent reasons not to use hypothetical frequencies as idealizations, but no reason not to use them as (...) approximations. (shrink)

Philosophers often make exotic-sounding modal claims, such as: “A timeless world is impossible”, “The laws of physics could have been different from what they are”, “There could have been an additional phenomenal colour”. Otherwise popular empiricist modal epistemologies in the contemporary literature cannot account for whatever epistemic justification we might have for making such modal claims. Those who do not, as a result of this, endorse scepticism with respect to their epistemic status typically suggest that they can be justified but (...) have yet to develop some distinct, workable theory of how. That is, they endorse a form of non-uniformism about the epistemology of modality, according to which claims about philosophically interesting modal matters need to be justified differently from e.g. everyday or scientific modal claims, but they fail to provide any more detail. This article aims to fill this gap by outlining how such a non-uniformist view could be spelled out and what story about philosophically interesting modal justification it could contain. (shrink)

Research in pharmacogenomics and precision medicine has recently introduced the concept of Polygenic Scores (PGSs), namely, indexes that aggregate the effects that many genetic variants are predicted to have on individual disease risk. The popularity of PGSs is increasing rapidly, but surprisingly little attention has been paid to the idealisations they make about phenotypic development. Indeed, PGSs rely on quantitative genetics models and methods, which involve considerable theoretical assumptions that have been questioned on various grounds. This comes with epistemological and (...) ethical concerns about the use of PGSs in clinical decision-making. In this paper, I investigate to what extent idealisations in genetics models can impact the data gathering and clinical interpretation of genomics findings, particularly the calculation and predictive accuracy of PGSs. Although idealisations are considered ineliminable components of scientific models, they may be legitimate or not depending on the epistemic aims of a model. I thus analyse how various idealisations have been introduced in classical models and progressively readapted throughout the history of genetic theorising. Notably, this process involved important changes in the epistemic purpose of such idealisations, which raises the question of whether they are legitimate in the context of contemporary genomics. (shrink)

How can a reflective scientist put forward an explanation using a model when they are aware that many of the assumptions used to specify that model are false? This paper addresses this challenge by making two substantial assumptions about explanatory practice. First, many of the propositions deployed in the course of explaining have a non-representational function. In particular, a proposition that a scientist uses and also believes to be false, i.e. an “idealization”, typically has some non-representational function in the practice, (...) such as the interpretation of some model or the specification of the target of the explanation. Second, when an agent puts forward an explanation using a model, they usually aim to remain agnostic about various features of the phenomenon being explained. In this sense, explanations are intended to be autonomous from many of the more fundamental features of such systems. I support these two assumptions by showing how they allow one to address a number of recent concerns raised by Bokulich, Potochnik and Rice. In addition, these assumptions lead to a defense of the view that explanations are wholly true that improves on the accounts developed by Craver, Mäki and Strevens. (shrink)

The literature on values in science struggles with questions about how to describe and manage the role of values in scientific research. We argue that progress can be made by shifting this literature’s current emphasis. Rather than arguing about how non-epistemic values can or should figure into scientific assessment, we suggest analyzing how scientific assessment can accommodate non-epistemic values. For scientific assessment to do so, it arguably needs to incorporate goals that have been traditionally characterized as non-epistemic. Building on this (...) insight, we show how the adequacy-for-purpose framework recently developed for assessing scientific models can provide a general framework for describing scientific assessment so that it goes beyond purely epistemic considerations. Adopting this framework has significant advantages and opens the possibility of effecting a partial rapprochement between critics and proponents of the value-free ideal. (shrink)

The Modern Synthesis has received criticism for its purported gene-centrism. That criticism relies on a concept of the gene as a unit of instructional information. In this paper I discuss information concepts and endorse one, developed from Floridi, that sees information as a functional relationship between data and context. I use this concept to inspect developmental criticisms of the Modern Synthesis and argue that the instructional gene arose as an idealization practice when evolutionary biologists made comment on development. However, a (...) closer inspection of key claims shows that at least some associated with the Modern Synthesis were in fact adopting the data led definition I favour and made clear arguments for the role of developmental processes beyond genetic input. There was no instructional gene. (shrink)

Yarkoni makes a number of valid points in his critical analysis of psychology, but he misses an opportunity to expose the root of its problems. That root is the poor practice around the derivation of explanatory constructs. We make comment on this with an example from behaviorist history and relate this to the recent discussion of scientific understanding in the philosophy of science.

The main purpose of this dissertation is to examine critically and discuss the role of imagination in science and religion, with particular emphasis on its possible epistemic, creative, and meaning-making functions. In order to answer my research questions, I apply theories and concepts from contemporary philosophy of mind on scientific and religious practices. This framework allows me to explore the mental state of imagination, not as an isolated phenomenon but, rather, as one of many mental states that co-exist and interplay (...) in our cogntive architecture. Based on the philosophical discourse of philosophy of mind, four types of imagination are indentified and conceptualized: sensory, propositional, experiential, and creative imagination. These categories are then employed on five phenomena that can be found in scientific and religious environments: metaphors, models, thought experiments, aspect perception, and - in the religious case - rituals. In relation to the concept of religious "seeing" I consider how imaginings may influence visionary experiences and visualization, and compare these phenomena with cases of scientific visualization and eureka experiences. In regard to scientific and religious models, a distinction is made between, on the one hand, two notions of truth and, on the other hand, truth-independent meaning-making. In light of these categories, I differentiate between, and critically discuss, the use of imagination in doxastic, non-doxastic and fictionalist accounts. In light of this investigation, I formulate and defend the position of interactivism, which acknowledges a constant interplay between different attitudes and mental states. In my examination of rituals and scientific and religious thought experiments, special attention is given to the mental capacity to recreate the experiences that are entailed in an imagined scenario. At the end of the investigation, I consider the possible impact that my study might have on how we view science and religion as well as the dialogue bewteen these two fields. (shrink)

According to a recent proposal, the epistemic aim of metaphysics as a discipline is to chart the different viable theories of metaphysical objects of inquiry (e.g. causation, persistence). This paper elaborates on and seeks to improve on that proposal in two related ways. First, drawing on an analogy with how-possibly explanation in science, I argue that we can usefully understand this aim of metaphysics as the charting of epistemically possible answers to metaphysical questions. Second, I argue that in order to (...) account for the epistemic goodness of this aim, one should appeal to the epistemic value it has in virtue of providing resources for non-factive understanding of the objects of metaphysical inquiry.**This paper is forthcoming in a special issue of Argumenta on the Epistemology of Metaphysics**. (shrink)

In his chapter in this volume, Christopher Pincock develops an argument for scientific realism based on scientific understanding, and he argues that Giere’s (2006) and my (2017, 2020) commitment to the context-dependence of scientific understanding or knowledge renders our views unable to account for an essential step in how scientists come to know. Meanwhile, in my chapter in this volume, I motivate a view that I call "causal pattern realism." In this response to Pincock's chapter, I will sketch a revised (...) version of Pincock’s argument for realism that is consistent with causal pattern realism. Then I will respond to Pincock’s concern that the context-dependence of understanding on my view would interfere with the scientific community’s ability to extrapolate from specific experimental and observational contexts as needed to develop knowledge. My goal is not to convince anyone to be a causal pattern realist but rather to create the space for such a view, taking into account the concerns motivating Pincock. (shrink)