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  1. Adaptive immunity or evolutionary adaptation? Transgenerational immune systems at the crossroads.Sophie Juliane Veigl - 2022 - Biology and Philosophy 37 (5):1-21.
    In recent years, immune systems have sparked considerable interest within the philosophy of science. One issue that has received increased attention is whether other phyla besides vertebrates display an adaptive immune system. Particularly the discovery of CRISPR-Cas9-based systems has triggered a discussion about how to classify adaptive immune systems. One question that has not been addressed yet is the transgenerational aspect of the CRISPR-Cas9-based response. If immunity is acquired and inherited, how to distinguish evolutionary from immunological adaptation? To shed light (...)
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  • Philosophy of CRISPR-Cas: Introduction to Eugene Koonin’s target paper and commentaries.Thomas Pradeu - 2019 - Biology and Philosophy 34 (1):16.
    In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be reduced to, defence against nonself. CRISPR-Cas systems can target endogenous elements and tolerate exogenous elements. We conclude that the vocabulary of “defence” and “nonself” might be misleading when describing CRISPR-Cas systems.
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  • Not by structures alone: Can the immune system recognize microbial functions?Gregor P. Greslehner - 2020 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 84 (C):101336.
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